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CD79a Antikörper (AA 208-222)

CD79A Reaktivität: Human, Maus, Ratte, Rind (Kuh), Schwein, Huhn, Pferd, Kaninchen, Meerschweinchen, Hund, Non-Human Primate FACS, WB, IHC (p), IP Wirt: Maus Monoclonal HM47 unconjugated
Produktnummer ABIN2749074
  • Target Alle CD79a (CD79A) Antikörper anzeigen
    CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
    Bindungsspezifität
    • 69
    • 25
    • 10
    • 10
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 208-222
    Reaktivität
    • 191
    • 101
    • 80
    • 51
    • 50
    • 32
    • 27
    • 25
    • 25
    • 25
    • 15
    • 10
    • 5
    • 4
    • 2
    • 1
    Human, Maus, Ratte, Rind (Kuh), Schwein, Huhn, Pferd, Kaninchen, Meerschweinchen, Hund, Non-Human Primate
    Wirt
    • 105
    • 100
    • 3
    • 1
    Maus
    Klonalität
    • 126
    • 82
    • 1
    Monoklonal
    Konjugat
    • 92
    • 19
    • 16
    • 15
    • 15
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD79a Antikörper ist unkonjugiert
    Applikation
    • 118
    • 96
    • 64
    • 58
    • 46
    • 24
    • 22
    • 14
    • 10
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
    Spezifität
    The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
    Kreuzreaktivität (Details)
    Human, Non-Human Primates, Porcine, Mouse, Rat, Bovine, Canine (Dog), Equine (Horse), Guinea pig, Rabbit, Chicken
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
    Klon
    HM47
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product CD79A Primärantikörper
  • Applikationshinweise
    Flow cytometry: Recommended dilution: 1-4 μg/mL, intracellular staining.
    Western blotting: Recommended dilution: 1-2 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Zhao, Hassan, Perry, Ning, Stass, Dehner: "C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." in: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).

    Bhargava, Kallakury, Ross, Azumi, Bagg: "CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone-dependent manner." in: American journal of clinical pathology, Vol. 128, Issue 2, pp. 306-13, (2007) (PubMed).

    Fernandez, West, Jackson, Kidney: "Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors." in: Veterinary pathology, Vol. 42, Issue 4, pp. 437-45, (2005) (PubMed).

    Islas-Ohlmayer, Padgett-Thomas, Domiati-Saad, Melkus, Cravens, Martin, Netto, Garcia: "Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein-Barr virus." in: Journal of virology, Vol. 78, Issue 24, pp. 13891-900, (2004) (PubMed).

    Torlakovic, Torlakovic: "B-cell markers in lymphocyte predominance Hodgkin disease." in: Archives of pathology & laboratory medicine, Vol. 126, Issue 7, pp. 862-3, (2002) (PubMed).

    Rassenti, Kipps: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." in: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).

    Mason, Cordell, Tse, van Dongen, van Noesel, Micklem, Pulford, Valensi, Comans-Bitter, Borst: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).

  • Target
    CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
    Andere Bezeichnung
    CD79a (CD79A Produkte)
    Synonyme
    CD79A antikoerper, Ig-alpha antikoerper, Iga antikoerper, Igalpha antikoerper, Ly-54 antikoerper, Ly54 antikoerper, mb-1 antikoerper, IGA antikoerper, MB-1 antikoerper, IG-alpha antikoerper, CD79a molecule antikoerper, CD79A antigen (immunoglobulin-associated alpha) antikoerper, Cd79a molecule-like antikoerper, CD79A antikoerper, Cd79a antikoerper, Cd79al antikoerper
    Hintergrund
    CD79a molecule,CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR alpha, Ig-alpha, MB-1, IGA
    Gen-ID
    973
    UniProt
    P11912
    Pathways
    BCR Signaling
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