CABLES1 Antikörper

Produktnummer ABIN272292

Produktdetails anti-CABLES1 Antikörper

Target: CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CABLES1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Cables1 protein. (region surrounding Lys588)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CABLES1

Target: CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))

Andere Bezeichnung: CABLES1 (CABLES1 Produkte)

Synonyme: CABLES1 antikoerper, si:dkey-2p18.3 antikoerper, CABL1 antikoerper, CABLES antikoerper, HsT2563 antikoerper, IK3-1 antikoerper, Cables antikoerper, ik3-1 antikoerper, Cdk5 and Abl enzyme substrate 1 antikoerper, CDK5 and Abl enzyme substrate 1 antikoerper, CABLES1 antikoerper, cables1 antikoerper, CpipJ_CPIJ019832 antikoerper, Cables1 antikoerper

Hintergrund: Normal Abl function is essential for humans because Philadelphia chromosome translocation involving the ABL gene causes chronic myelogenous leukemia. Abl associates with a broad range of targets and appears to function in various signaling pathways. Cables, a 568 amino-acid protein, links Abl to cyclin-dependent kinase 5 (Cdk5). Cables bound to Cdk5 functions as a substrate for phosphorylation by the Cdk5/p35 kinase. Cables contains an area of weak homology to cyclin A and cyclin C. In addition to its C-terminal Cdk5 binding domain, Cables also has six potential SH3 binding motifs (PXXP) clustered around the amino terminus, two of which are similar to motifs known to bind the Abl SH3 domain. Cables forms a trimolecular complexwith Cdk5 and Abl in vivo. All three proteins colocalize within cortical axons, particularly in their growth cones. Cables and Abl may function as adaptor or scaffolding proteins to bind to Cdk5 and control its subcellular location in the neuron.Synonyms: CDK5 and ABL1 enzyme substrate 1, Ik3-1, Interactor with CDK3 1

Molekulargewicht: approx. 67 kDa

Gen-ID: 91768

NCBI Accession: NP_001094089

UniProt: Q8TDN4