CYP27A1 Antikörper

Produktnummer ABIN272272

Produktdetails anti-CYP27A1 Antikörper

Target: CYP27A1 (Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP27A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects endogenous levels of CYP27A1 protein. (region surrounding Glu131)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Referenzen für anti-CYP27A1 Antikörper (ABIN272272)

Duan, Fu, Wang, Ni, Zhao: "Cholesterol deregulation induced by chronic corticosterone (CORT) stress in pectoralis major of broiler chickens." in: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Vol. 176, pp. 59-64, (2014) (PubMed).

Haag, Stadel, Zhou, Bachem, Möller, Debatin, Fulda: "Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells." in: Gut, Vol. 60, Issue 2, pp. 225-37, (2011) (PubMed).

Korzekwa, Bah, Kurzynowski, Lukasik, Groblewska, Skarzynski: "Leukotrienes modulate secretion of progesterone and prostaglandins during the estrous cycle and early pregnancy in cattle: an in vivo study." in: Reproduction (Cambridge, England), Vol. 140, Issue 5, pp. 767-76, (2011) (PubMed).

Details zu CYP27A1

Target: CYP27A1 (Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1))

Andere Bezeichnung: CYP27A1 (CYP27A1 Produkte)

Synonyme: CP27 antikoerper, CTX antikoerper, CYP27 antikoerper, Cyp27 antikoerper, P450C27 antikoerper, 1300013A03Rik antikoerper, cytochrome P450 family 27 subfamily A member 1 antikoerper, cytochrome P450, family 27, subfamily a, polypeptide 1 antikoerper, cytochrome P450, family 27, subfamily A, polypeptide 1 antikoerper, sterol 26-hydroxylase, mitochondrial antikoerper, CYP27A1 antikoerper, Cyp27a1 antikoerper, cyp27a1 antikoerper

Hintergrund: The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity.Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is involved in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication.Synonyms: 12-alpha-triol 27-hydroxylase, 5-beta-cholestane-3-alpha, 7-alpha, CYP27, Cytochrome P-450C27/25, Cytochrome P450 27, Sterol 26-hydroxylase, Sterol 27-hydroxylase, Vitamin D3-25-hydroxylase

Molekulargewicht: approx. 60 kDa

Gen-ID: 1593

NCBI Accession: NP_000775

UniProt: Q02318