PTPN13 Antikörper (AA 2290-2491)

Produktnummer ABIN2712101

Produktdetails anti-PTPN13 Antikörper

Target: PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))

Bindungsspezifität: AA 2290-2491

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPN13 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody reacts to Fas-associated Protein Tyrosine Phosphatase 1 (FAP-1) (PTPN13).

Aufreinigung: Immunoaffinity Chromatography

Immunogen: PTPN13 antibody was raised against recombinant protein encoding aa 2290-2491 of human FAP-1 Genename: PTPN13

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 10 mM PBS, pH 7.4, BSA, sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PTPN13

Target: PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))

Andere Bezeichnung: PTPN13 (PTPN13 Produkte)

Synonyme: FAP-1 antikoerper, PNP1 antikoerper, PTP-BAS antikoerper, PTP-BL antikoerper, PTP1E antikoerper, PTPL1 antikoerper, PTPLE antikoerper, hPTP1E antikoerper, PTPN13 antikoerper, AI324989 antikoerper, Ptpri antikoerper, RIP antikoerper, Ptp-bl antikoerper, ptp antikoerper, wu:fb50g04 antikoerper, zgc:162319 antikoerper, protein tyrosine phosphatase, non-receptor type 13 antikoerper, tyrosine-protein phosphatase non-receptor type 13 antikoerper, PTPN13 antikoerper, LOC100540743 antikoerper, ptpn13 antikoerper, Ptpn13 antikoerper

Hintergrund: Fas-associated phosphatase-1 (FAP-1), a NT7 non-receptor protein tyrosine phosphatase, is comprised of a N-terminal FERM domain, five PDZ domains, and a C-terminal tyrosine phosphatase domain. The protein has been shown to bind the cytosolic tail of Fas (Apo1, CD95) and regulate Fas-induced apoptosis. Human tumor cell lines become resistant to Fas-mediated apoptosis when transfected with FAP-1, indicating that FAP-1 functions as a negative regulator in Fas-mediated death signaling. FAS resistance has been documented in a variety of cancers, including cancer of the lung, ovary, pancreas, and liver. At least three protein isoforms of FAP-1 have been reported. Alterations in FAP-1 expression have been shown to result in defects in cytokinesis.Synonyms: FAP1, Fas-associated protein-tyrosine phosphatase 1, PNP1, PTP-BAS, PTP-E1, PTP1E, PTPL1, Protein-tyrosine phosphatase 1E, Protein-tyrosine phosphatase PTPL1, Tyrosine-protein phosphatase non-receptor type 13

Gen-ID: 5783

NCBI Accession: NP_006255

UniProt: Q12923