Reacts with the core peptide of the MUC2 protein, a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kD) and an amino acid composition rich in serine, threonin, proline and glycine. The core protein contains a domain of 23 amino-acid tandem repeats which function as multiple epitopes for the monoclonal antibody. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This antibody has been shown to be relatively tissue specific, being associated predominantly with intestinal tissue and is highly reactive with colon and gastric tumors. The antibody is suitable for staining formalin-fixed, paraffin-embedded tissue sections following citrate pretreatment.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store undiluted at 4°C.
Devine, Birrell, Whitehead, Harada, Xing, McKenzie: "Expression of MUC1 and MUC2 mucins by human tumor cell lines." in: Tumour biology, Vol. 13, Issue 5-6, pp. 268-77, (1993) (PubMed).
Xing, Prenzoska, Layton, Devine, McKenzie: "Second-generation monoclonal antibodies to intestinal MUC2 peptide reactive with colon cancer." in: Journal of the National Cancer Institute, Vol. 84, Issue 9, pp. 699-703, (1992) (PubMed).