IL-21 Antikörper (Biotin)

Produktnummer ABIN2689755

Produktdetails anti-IL-21 Antikörper (Biotin)

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-21 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Marke: BD Pharmingen™

Produktmerkmale: The I76-539 antibody reacts with interleukin-21 (IL-21), an ~ 15 kDa member of the type-I-cytokine family of proteins. IL-21 is expressed primarily by CD4+ T cells and has a broad range of immunoregulatory functions on B cells, CD8+ T cells, NK cells and dendritic cells. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells and augmentation of antitumor activity of CD8+ T cells. It has been speculated that IL-21, through its varies positive and negative regulatory effects on cell-mediated and humoral immunity, may play a role in autoimmuninty, allergy, asthma and tumor regression. Human IL-21 sandwich ELISA curve: The curve was generated by a sandwich ELISA using the purified J148-1134 as capture antibody(Cat. No. 558503), doubling dilutions of recombinant human IL-21 protein and biotin I76-539 as detection antibody. Streptavidin-HRP (Cat. No. 554066) plus TMB substrate (Cat. No. 555214)were used to develop the ELISA.

BD Pharmingen™ Biotin Mouse anti-Human IL-21 - Biotin - Clone I76-539 - Isotype Mouse IgG1, κ - 0.5 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human IL-21

Klon: I76

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-IL-21 Antikörper (Biotin) (ABIN2689755)

Leonard, Spolski: "Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation." in: Nature reviews. Immunology, Vol. 5, Issue 9, pp. 688-98, (2005) (PubMed).

Sivakumar, Foster, Clegg: "Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses." in: Immunology, Vol. 112, Issue 2, pp. 177-82, (2004) (PubMed).

Details zu IL-21

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Andere Bezeichnung: IL-21 (IL21 Produkte)

Synonyme: IL-21 antikoerper, Za11 antikoerper, interleukin 21 antikoerper, IL21 antikoerper, Il21 antikoerper

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response