LILRB1 Antikörper

Produktnummer ABIN2689417

Produktdetails anti-LILRB1 Antikörper

Target: LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LILRB1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Fluorescence Microscopy (FM)

Marke: BD Pharmingen™

Produktmerkmale: CD85 Molecules belong to a large immunoregulatory family and it has been clustered into different subclasses from CD85a to CD85m in the VIIth HLDA workshop. CD85j is also called as Ig-like transcript (ILT2), or leukocyte Ig-like receptor (LIR-1). Reacts with an 110 kDa membrane glycoprotein expressed on a subset of NK cells, which varies amongst individuals, and a subpopulation of T lymphocytes. Expression on T lymphocytes, NK cells may depend on the individuals tested. Function studies show that ligation of ILT2 with MHC class I including HLA-A, B, G1 and -E induces an inhibitory signal via recruitment of SHP-1 phosphatase. This antibody is routinely tested by flow cytometric analysis and fluorescence microscopy. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD85j - Purified - Clone GHI/75 - Isotype Mouse IgG2b, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: GHI-75

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-LILRB1 Antikörper (ABIN2689417)

Colonna, Nakajima, Navarro, López-Botet: "A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells." in: Journal of leukocyte biology, Vol. 66, Issue 3, pp. 375-81, (1999) (PubMed).

Pulford, Micklem, Thomas, Jones, Mason: "A 72-kD B cell-associated surface glycoprotein expressed at high levels in hairy cell leukaemia and plasma cell neoplasms." in: Clinical and experimental immunology, Vol. 85, Issue 3, pp. 429-35, (1991) (PubMed).

McArdle, Knight, Halliday, Muller, Rowden: "Quantitative assessment of Langerhans cells in actinic keratosis, Bowen's disease, keratoacanthoma, squamous cell carcinoma and basal cell carcinoma." in: Pathology, Vol. 18, Issue 2, pp. 212-6, (1986) (PubMed).

Details zu LILRB1

Target: LILRB1 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 1 (LILRB1))

Andere Bezeichnung: CD85j (LILRB1 Produkte)

Synonyme: CD85J antikoerper, ILT-2 antikoerper, ILT2 antikoerper, LIR-1 antikoerper, LIR1 antikoerper, MIR-7 antikoerper, MIR7 antikoerper, leukocyte immunoglobulin like receptor B1 antikoerper, LILRB1 antikoerper

Hintergrund: Synonyms: CD85

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response