CD79b Antikörper

Produktnummer ABIN2689397

Produktdetails anti-CD79b Antikörper

Target: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD79b Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Immunoglobulin (Ig) antigen receptors are composed of a non-covalently-associated complex of Ig and two other proteins, Igα and Igβ, clustered as CD79a and CD79b, respectively. CD79b is a membrane glycoprotein of 229 residues, with a predicted relative molecular mass of 36-40 kDa. Its expression is restricted to B lineage cells, has been reported to associate with surface IgM receptor, and may be involved in signal transduction. Antibody 3A2-2E7 (also known as SN8) was generated by immunization of cell membrane preparations from B-prolymphocytic leukemia cells. It has similar reactivity characteristics as clone CB3-1 (another CD79b available from BD Biosciences Pharmingen, Cat. No. 555678). Antibodies CD3-1 and 3A2-2E7 reacts with an epitope that is enhanced on certain B-cell leukemias such as prolymphocytic leukemia and lymphoma, but not on chronic lymphocytic leukemia. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of human CD79b expression on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD79b - Purified - Clone 3A2-2E7 (also known as SN8) - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: 3A2

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-CD79b Antikörper (ABIN2689397)

Cragg, Chan, Fox, Tutt, Smith, Oscier, Hamblin, Glennie: "The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis." in: Blood, Vol. 100, Issue 9, pp. 3068-76, (2002) (PubMed).

Van Kooten, Galibert, Seon, Garrone, Liu, Banchereau: "Cross-linking of antigen receptor via Ig-beta (B29, CD79b) can induce both positive and negative signals in CD40-activated human B cells." in: Clinical and experimental immunology, Vol. 110, Issue 3, pp. 509-15, (1998) (PubMed).

Moreau, Matutes, AHern, Morilla, Morilla, Owusu-Ankomah, Seon, Catovsky: "Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b)." in: American journal of clinical pathology, Vol. 108, Issue 4, pp. 378-82, (1997) (PubMed).

Zomas, Matutes, Morilla, Owusu-Ankomah, Seon, Catovsky: "Expression of the immunoglobulin-associated protein B29 in B cell disorders with the monoclonal antibody SN8 (CD79b)." in: Leukemia, Vol. 10, Issue 12, pp. 1966-70, (1997) (PubMed).

Astsaturov, Matutes, Morilla, Seon, Mason, Farahat, Catovsky: "Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia." in: Leukemia, Vol. 10, Issue 5, pp. 769-73, (1996) (PubMed).

Okazaki, Luo, Han, Yoshida, Seon: "Three new monoclonal antibodies that define a unique antigen associated with prolymphocytic leukemia/non-Hodgkin's lymphoma and are effectively internalized after binding to the cell surface antigen." in: Blood, Vol. 81, Issue 1, pp. 84-94, (1993) (PubMed).

Details zu CD79b

Target: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Andere Bezeichnung: CD79b (CD79B Produkte)

Synonyme: B29 antikoerper, Ig-beta antikoerper, Igb antikoerper, Igbeta antikoerper, AGM6 antikoerper, IGB antikoerper, CD79B antigen antikoerper, CD79b molecule antikoerper, Cd79b antikoerper, CD79B antikoerper

Hintergrund: Synonyms: Igβ/SN8/3A2-2E7-1F5

Pathways: BCR Signaling