Integrin beta 3 Antikörper

Produktnummer ABIN2689353

Produktdetails anti-Integrin beta 3 Antikörper

Target: Integrin beta 3 (ITGB3)

Reaktivität: Maus, Ratte

Wirt: Armenischer Hamster

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Marke: BD Pharmingen™

Produktmerkmale: The 2C9.G2 antibody reacts with the integrin β3 chain (CD61), which associates with the integrin αv chain (CD51) to form the vitronectin receptor and with the αIIb chain (CD41) to form the gpIIb/IIIa complex. Both receptors mediate adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is also mediated by the binding of αvβ3 integrin or vitronectin receptor to CD31 (PECAM-1). In addition, interaction of the αvβ3 integrin with its ligands regulates the L-type Ca2+ channel in vascular smooth muscle cells, possibly mediating vasodilatory responses to injury. Soluble and insoluble 2C9.G2 mAb mimics the effect of the natural ligands in smooth muscle cells from rat cremaster arterioles. Furthermore, osteopontin, also named Eta-1, is a cytokine that binds to αvβ3. CD61 is expressed on platelets, activated T lymphocytes, polymorphonuclear granulocytes, and blastocysts. Cross-reactivity of mAb 2C9.G2 to rat mast cells and platelets has been observed by flow cytometric analysis. mAb 2C9.G2 has been demonstrated to block binding of rat and mouse cells to fibronectin. Immunohistochemical staining of CD61 positive cells. Frozen sections of normal mouse spleen were reacted with the anti-CD61 antibody. Cells positive for CD61 can be identified by the brown labeling of their cell membranes. Amplification 20X.

BD Pharmingen™ Purified Hamster Anti-Mouse CD61 - Purified - Clone 2C9.G2 - Isotype Armenian Hamster IgG1, κ - Reactivity Ms, Rat - 1 mL

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse T-cell Hybridoma 2B4 Vitronectin Receptor

Klon: 2C9-G2

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-Integrin beta 3 Antikörper (ABIN2689353)

Ashkar, Weber, Panoutsakopoulou, Sanchirico, Jansson, Zawaideh, Rittling, Denhardt, Glimcher, Cantor: "Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity." in: Science (New York, N.Y.), Vol. 287, Issue 5454, pp. 860-4, (2000) (PubMed).

Piali, Hammel, Uherek, Bachmann, Gisler, Dunon, Imhof: "CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium." in: The Journal of cell biology, Vol. 130, Issue 2, pp. 451-60, (1995) (PubMed).

Yasuda, Hasunuma, Adachi, Sekine, Sakanishi, Hashimoto, Ra, Yagita, Okumura: "Expression and function of fibronectin binding integrins on rat mast cells." in: International immunology, Vol. 7, Issue 2, pp. 251-8, (1995) (PubMed).

Kieffer, Phillips: "Platelet membrane glycoproteins: functions in cellular interactions." in: Annual review of cell biology, Vol. 6, pp. 329-57, (1991) (PubMed).

Moulder, Roberts, Shevach, Coligan: "The mouse vitronectin receptor is a T cell activation antigen." in: The Journal of experimental medicine, Vol. 173, Issue 2, pp. 343-7, (1991) (PubMed).

Details zu Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Andere Bezeichnung: CD61 (ITGB3 Produkte)

Synonyme: BDPLT16 antikoerper, BDPLT2 antikoerper, CD61 antikoerper, GP3A antikoerper, GPIIIa antikoerper, GT antikoerper, INGRB3 antikoerper, integrin antikoerper, INTB3 antikoerper, GPIIIA antikoerper, cd61 antikoerper, gp3a antikoerper, itgb3 antikoerper, itgb3.2 antikoerper, itgb3.1 antikoerper, integrin subunit beta 3 antikoerper, integrin beta 3 antikoerper, integrin subunit beta 3 L homeolog antikoerper, integrin beta 3a antikoerper, integrin beta 3b antikoerper, ITGB3 antikoerper, Itgb3 antikoerper, itgb3.L antikoerper, itgb3a antikoerper, itgb3b antikoerper

Hintergrund: Synonyms: Integrin β3 chain

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex