ITGA4 Antikörper

Produktnummer ABIN2689306

Produktdetails anti-ITGA4 Antikörper

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reaktivität: Human, Rind (Kuh), Hund, Pferd, Cat, Schaf, Cynomolgus, Pavian, Rhesusaffen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ITGA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Reaacts with the integrin α4 chain, which is expressed as a heterodimer with either of two β subunits, β1 (CD29) or β7. The α4β1 integrin (VLA-4) is expressed on lymphocytes, monocytes, thymocytes, NK cells, and several B- and T-cell lines, and mediates binding to VCAM-1 (CD106) and the CS-1 region of fibronectin. The α4β7 integrin has a similar tissue distribution, except it is found on only a small subpopulation of thymocytes. Integrin α4β7 also binds fibronectin and VCAM-1, and has been shown in the mouse to preferentially bind the mucosal vascular addressin molecule, MAdCAM-1. This antibody is useful for studies of the expression and function of a4 chain-containing integrins. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed on a FACScan

BD Pharmingen™ Purified Mouse Anti-Human CD49d - Purified - Clone 9F10 - Isotype Mouse IgG1, κ - Reactivity Hu, Bab, Cat, Cow, Cyno, Dog, Hs, Rhe, Sheep - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: 9F10

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-ITGA4 Antikörper (ABIN2689306)

Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, (1993) (PubMed).

Parker, Cepek, Russell, Shaw, Posnett, Schwarting, Brenner: "A family of beta 7 integrins on human mucosal lymphocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 5, pp. 1924-8, (1992) (PubMed).

Hemler, Huang, Takada, Schwarz, Strominger, Clabby: "Characterization of the cell surface heterodimer VLA-4 and related peptides." in: The Journal of biological chemistry, Vol. 262, Issue 24, pp. 11478-85, (1987) (PubMed).

Details zu ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Andere Bezeichnung: CD49d (ITGA4 Produkte)

Synonyme: CD49D antikoerper, IA4 antikoerper, LOC100219853 antikoerper, integrin subunit alpha 4 antikoerper, integrin alpha 4 antikoerper, integrin subunit alpha 4 S homeolog antikoerper, ITGA4 antikoerper, Itga4 antikoerper, itga4.S antikoerper

Hintergrund: Synonyms: Integrin α4 chain

Pathways: Integrin Complex