TNFRSF4 Antikörper (Biotin)

Produktnummer ABIN2688958

Produktdetails anti-TNFRSF4 Antikörper (Biotin)

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFRSF4 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: The OX-40 antibody reacts with the 50- kDa OX-40 Antigen (CD134), also known as OX-40 Receptor, on CD4+ T lymphocytes activated in vitro and in vivo. The antigen is a member of the NGFR/TNFR superfamily, which includes low-affinity nerve growth factor receptor, TNF receptors, the Fas antigen, CD137 (4-1BB), CD27, CD30, and CD40. CD134 supplies costimulatory signals for T-cell proliferation and effector functions. While OX-40 mAb is not mitogenic, it does augment some in vitro T-cell responses. It is also reported to block binding of OX-40 Ligand to OX-40 Antigen.

BD Pharmingen™ Biotin Mouse Anti-Rat CD134 - Biotin - Clone OX-40 - Isotype Mouse IgG2b, κ - Reactivity Rat - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Activated rat lymph node cells

Klon: OX

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Referenzen für anti-TNFRSF4 Antikörper (Biotin) (ABIN2688958)

Weinberg, Vella, Croft: "OX-40: life beyond the effector T cell stage." in: Seminars in immunology, Vol. 10, Issue 6, pp. 471-80, (1999) (PubMed).

al-Shamkhani, Birkeland, Puklavec, Brown, James, Barclay: "OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand." in: European journal of immunology, Vol. 26, Issue 8, pp. 1695-9, (1996) (PubMed).

Smith, Farrah, Goodwin: "The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death." in: Cell, Vol. 76, Issue 6, pp. 959-62, (1994) (PubMed).

Mallett, Fossum, Barclay: "Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor." in: The EMBO journal, Vol. 9, Issue 4, pp. 1063-8, (1990) (PubMed).

Details zu TNFRSF4

Target: TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))

Andere Bezeichnung: CD134 (TNFRSF4 Produkte)

Synonyme: TNFRSF4 antikoerper, ACT35 antikoerper, CD134 antikoerper, Ly-70 antikoerper, Ox40 antikoerper, TXGP1L antikoerper, Txgp1 antikoerper, OX40 antikoerper, TNF receptor superfamily member 4 antikoerper, tumor necrosis factor receptor superfamily, member 4 antikoerper, TNFRSF4 antikoerper, Tnfrsf4 antikoerper

Hintergrund: Synonyms: OX-40 Antigen

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints