IFNGR1 Antikörper (Biotin)

Produktnummer ABIN2688898

Produktdetails anti-IFNGR1 Antikörper (Biotin)

Target: IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser IFNGR1 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: The GR20 antibody reacts with CD119, the α chain of the interferon γ (IFN-γ) receptor. This receptor is expressed by mouse leukocytes, endothelial, and epithelial cells, but not by mature erythrocytes. GR20 mAb recognizes an epitope (susceptible to certain fixatives) in the ligand-binding site of the receptor. It can block the binding of mouse IFN-γ, therefore, it can inhibit IFN-γ .mediated effects including the activation of mouse macrophages for tumor cell killing. IFN-γ has been reported to induce the expression of Ly-6A/E antigen on cell lines and normal B lymphocytes, and the GR20 antibody is capable of inhibiting the IFN-γ.induced expression of Ly-6A/E on the mouse B lymphoma line A20. The binding of the GR20 antibody to CD119 is inhibited by IFN-γ. This antibody reportedly does not have any agonist effect.

BD Pharmingen™ Biotin Rat Anti-Mouse CD119 - Biotin - Clone GR20 - Isotype Rat IgG2a, κ - Reactivity Ms - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: BALB/c mouse monomyelocytic cell line WEHI-3

Klon: GR20

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Referenzen für anti-IFNGR1 Antikörper (Biotin) (ABIN2688898)

LeClaire, Basu, Pinson, Redick, Hunt, Zavodny, Pace, Russell: "Characterization and use of monoclonal and polyclonal antibodies against the mouse interferon-gamma receptor." in: Journal of leukocyte biology, Vol. 51, Issue 5, pp. 507-16, (1992) (PubMed).

Cofano, Moore, Tanaka, Yuhki, Landolfo, Appella: "Affinity purification, peptide analysis, and cDNA sequence of the mouse interferon gamma receptor." in: The Journal of biological chemistry, Vol. 265, Issue 7, pp. 4064-71, (1990) (PubMed).

Codias, Malek: "Regulation of B lymphocyte responses to IL-4 and IFN-gamma by activation through Ly-6A/E molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 6, pp. 2197-204, (1990) (PubMed).

Basu, Pace, Pinson, Hayes, Trotta, Russell: "Purification and partial characterization of a receptor protein for mouse interferon gamma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 17, pp. 6282-6, (1988) (PubMed).

Details zu IFNGR1

Target: IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))

Andere Bezeichnung: CD119 (IFNGR1 Produkte)

Synonyme: CD119 antikoerper, IFNGR antikoerper, IFN-gammaR antikoerper, Ifgr antikoerper, Ifngr antikoerper, Nktar antikoerper, IFNGR1 antikoerper, MGC129098 antikoerper, ifngr1 antikoerper, MGC194858 antikoerper, MGC194873 antikoerper, zgc:194858 antikoerper, cd119 antikoerper, ifngr antikoerper, DKFZp469K1232 antikoerper, interferon gamma receptor 1 antikoerper, cytokine receptor family member B17 antikoerper, IFNGR1 antikoerper, Ifngr1 antikoerper, crfb17 antikoerper, ifngr1 antikoerper

Hintergrund: Synonyms: IFN-γ receptor α chain

Pathways: Interferon-gamma Pathway