CD103 Antikörper (Biotin)

Produktnummer ABIN2688874

Produktdetails anti-CD103 Antikörper (Biotin)

Target: CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD103 Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: The M290 antibody reacts with the α chain of αIELβ7 integrin. CD103 has a unique and fairly restricted tissue distribution. It is expressed on almost all intestinal intraepithelial lymphocytes (IEL), on dendritic epidermal T cells (DEC), on subpopulations of peripheral T cells, and on distinct subsets of fetal, neonatal, and adult thymocytes. E-cadherin is the epithelial-cell ligand for αIELβ7 integrin. The ordered expression of αIEL during thymocyte development (which occurs under the influence of the thymic epithelium), the high level of expression of αIEL on those peripheral T cells found in epithelial tissues (IEL and DEC), and the expression of CD103 on a subset of CD8+ lymphocytes responding to allogeneic epithelial cells suggest that αIELβ7 integrin may have a common role in the interactions of T lymphocytes with epithelia during T-cell maturation and effector functions. CD103 is thought to play a role in allograft rejection. The M290 antibody is reported to efficiently inhibit αIELβ7-mediated adhesion in in vitro assays.

BD Pharmingen™ Biotin Rat Anti-Mouse CD103 - Biotin - Clone M290 - Isotype Rat IgG2a, κ - Reactivity Ms - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse mammary tumor cells

Klon: M290

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Referenzen für anti-CD103 Antikörper (Biotin) (ABIN2688874)

Feng, Wang, Yuan, Parker, Farber, Hadley: "CD103 expression is required for destruction of pancreatic islet allografts by CD8(+) T cells." in: The Journal of experimental medicine, Vol. 196, Issue 7, pp. 877-86, (2002) (PubMed).

Hadley, Bartlett, Via, Rostapshova, Moainie: "The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 8, pp. 3748-56, (1997) (PubMed).

Karecla, Green, Bowden, Coadwell, Kilshaw: "Identification of a binding site for integrin alphaEbeta7 in the N-terminal domain of E-cadherin." in: The Journal of biological chemistry, Vol. 271, Issue 48, pp. 30909-15, (1997) (PubMed).

Andrew, Rott, Kilshaw, Butcher: "Distribution of alpha 4 beta 7 and alpha E beta 7 integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes." in: European journal of immunology, Vol. 26, Issue 4, pp. 897-905, (1996) (PubMed).

Karecla, Bowden, Green, Kilshaw: "Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin alpha M290 beta 7 (alpha E beta 7)." in: European journal of immunology, Vol. 25, Issue 3, pp. 852-6, (1995) (PubMed).

Lefrançois, Barrett, Havran, Puddington: "Developmental expression of the alpha IEL beta 7 integrin on T cell receptor gamma delta and T cell receptor alpha beta T cells." in: European journal of immunology, Vol. 24, Issue 3, pp. 635-40, (1994) (PubMed).

Roberts, Kilshaw: "The mucosal T cell integrin alpha M290 beta 7 recognizes a ligand on mucosal epithelial cell lines." in: European journal of immunology, Vol. 23, Issue 7, pp. 1630-5, (1993) (PubMed).

Kilshaw, Murant: "Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system." in: European journal of immunology, Vol. 21, Issue 10, pp. 2591-7, (1991) (PubMed).

Kilshaw, Murant: "A new surface antigen on intraepithelial lymphocytes in the intestine." in: European journal of immunology, Vol. 20, Issue 10, pp. 2201-7, (1990) (PubMed).

Kilshaw, Baker: "A unique surface antigen on intraepithelial lymphocytes in the mouse." in: Immunology letters, Vol. 18, Issue 2, pp. 149-54, (1988) (PubMed).

Details zu CD103

Target: CD103 (ITGAE) (Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE))

Andere Bezeichnung: CD103 (ITGAE Produkte)

Synonyme: A530055J10 antikoerper, CD103 antikoerper, aM290 antikoerper, alpha-E1 antikoerper, alpha-M290 antikoerper, HUMINAE antikoerper, integrin alpha E, epithelial-associated antikoerper, integrin subunit alpha E antikoerper, Itgae antikoerper, ITGAE antikoerper

Hintergrund: Synonyms: Integrin αIEL chain