ErbB2/Her2 Antikörper

Produktnummer ABIN2688859

Produktdetails anti-ErbB2/Her2 Antikörper

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Marke: BD Pharmingen™

Produktmerkmale: C-erbB-2 (also known as HER2/neu), a 185 kDa transmembrane glycoprotein, is a member of the type 1 growth factor receptor subfamily which also includes c-erbB-3, c-erbB-4 and the epidermal growth factor receptor (EGFR) (also known as c-erbB-1). Members of this receptor subfamily mediate the proliferation and differentiation of normal cells. They have a common structure consisting of an extracellular domain, a transmembrane region, and a cytoplasmic sequence. The extracellular regions contain two cysteine-rich domains, and the intracellular regions have sequence homology to known tyrosine kinases. C-erbB-3 reactivity has been detected in proximal kidney tubules, mucosal epithelium in the gastointenstinal tract, and squamous epithelium in skin. Most other normal adult tissue show little or no reactivity with antibodies against c-erbB-2, including breast, ovary, spleen, liver, bone marrow, prostate, adrenal, and lung. However, c-erbB-2 is overexpressed in many human breast, stomach, ovary and bladder carcinomas. EGFR, c-erbB-3 and c-erbB-4 are also overexpressed in various human tumor cells, and it is thought that aberrant activation of type 1 growth factor kinase activities may contribute to tumor progression.

BD Pharmingen™ Purified Mouse Anti-Human c-erbB-2 - Purified - Clone 9G6 - Isotype Mouse IgG1 - Reactivity Hu - 100 μg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Recombinant human c-erbB-2

Klon: 9G6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-ErbB2/Her2 Antikörper (ABIN2688859)

Stål, Sullivan, Sun, Wingren, Nordenskjöld: "Simultaneous analysis of c-erbB-2 expression and DNA content in breast cancer using flow cytometry." in: Cytometry, Vol. 16, Issue 2, pp. 160-8, (1994) (PubMed).

Carraway, Cantley: "A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling." in: Cell, Vol. 78, Issue 1, pp. 5-8, (1994) (PubMed).

Penault-Llorca, Adelaïde, Houvenaeghel, Hassoun, Birnbaum, Jacquemier: "Optimization of immunohistochemical detection of ERBB2 in human breast cancer: impact of fixation." in: The Journal of pathology, Vol. 173, Issue 1, pp. 65-75, (1994) (PubMed).

Schwechheimer, Läufle, Schmahl, Knödlseder, Fischer, Höfler: "Expression of neu/c-erbB-2 in human brain tumors." in: Human pathology, Vol. 25, Issue 8, pp. 772-80, (1994) (PubMed).

Rubin, Finstad, Wong, Almadrones, Plante, Lloyd: "Prognostic significance of HER-2/neu expression in advanced epithelial ovarian cancer: a multivariate analysis." in: American journal of obstetrics and gynecology, Vol. 168, Issue 1 Pt 1, pp. 162-9, (1993) (PubMed).

Singleton, Niehans, Gu, Litz, Hagen, Qiu, Kiang, Strickler: "Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry." in: Human pathology, Vol. 23, Issue 10, pp. 1141-50, (1992) (PubMed).

van de Vijver, Peterse, Mooi, Wisman, Lomans, Dalesio, Nusse: "Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer." in: The New England journal of medicine, Vol. 319, Issue 19, pp. 1239-45, (1988) (PubMed).

Details zu ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Andere Bezeichnung: C-ErbB-2 (ErbB2/Her2 Produkte)

Synonyme: CD340 antikoerper, HER-2 antikoerper, HER-2/neu antikoerper, HER2 antikoerper, MLN 19 antikoerper, NEU antikoerper, NGL antikoerper, TKR1 antikoerper, Erbb-2 antikoerper, Neu antikoerper, c-erbB2 antikoerper, c-neu antikoerper, mKIAA3023 antikoerper, wu:fv70f10 antikoerper, zgc:63601 antikoerper, erb2 antikoerper, erb-b2 receptor tyrosine kinase 2 antikoerper, ERBB2 antikoerper, Erbb2 antikoerper, erbb2 antikoerper

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development