CHD4 Antikörper (Chromodomain Helicase DNA Binding Protein 4) (AA 22-155)

Details for Product anti-CHD4 Antibody No. ABIN2668534, Anbieter: Anmelden zum Anzeigen
Antigen
  • CHD4
  • im:7143343
  • si:ch211-51m24.3
  • si:ch211-57k11.10
  • wu:fb44b12
  • wu:fd12d03
  • MGC145363
  • Mi-2b
  • Mi2-BETA
  • Mi-2
  • 9530019N15Rik
  • AA617397
  • BC005710
  • D6Ertd380e
  • Mi-2beta
  • mKIAA4075
  • b230399n07
  • chromodomain helicase DNA binding protein 4
  • chromodomain helicase DNA binding protein 4a
  • chromodomain helicase DNA binding protein 4b
  • chromodomain helicase DNA binding protein 4 L homeolog
  • CHD4
  • chd4a
  • chd4b
  • chd4
  • Chd4
  • chd4.L
Epitop
AA 22-155
5
4
4
4
3
2
2
2
2
2
2
1
1
1
Reaktivität
Human, Maus
83
52
12
4
4
4
4
4
4
2
1
1
1
1
1
Wirt
Kaninchen
45
41
2
Klonalität
Polyklonal
Konjugat
Dieser CHD4 Antikörper ist unkonjugiert
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
62
50
43
18
18
18
10
9
4
3
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This Mi-2B antibody was raised against a recombinant protein corresponding to amino acids 22-155 of mouse Mi-2 beta.
Reinigung None
Andere Bezeichnung Mi-2 beta (CHD4 Antibody Abstract)
Hintergrund Mi-2β (Mi-2beta, CHD4, chromodomain helicase DNA-binding protein 4) represents the major Mi-2 isoform present in the complex Mi-2/NuRD. This complex is a multi-subunit protein complex containing both histone deacetylase and nucleosome-dependent ATPase subunits. Current models predict that this complex functions primarily in transcriptional repression. In addition to the ATPase domain, Mi-2 beta contains a chromodomain and two PHD domains. Mi-2 beta interacts with BRG-1, a component of the SWI/SNF complex, and the RET finger protein (RFP).
Molekulargewicht 240 kDa
Gen-ID 1108
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Lagerung -20 °C
Informationen zur Lagerung Antibodies in solution can be stored at -20 °C for 2 years.
Haltbarkeit 6 months
Bilder des Herstellers
Immunofluorescence (IF) image for anti-Chromodomain Helicase DNA Binding Protein 4 (CHD4) (AA 22-155) antibody (ABIN2668534) Mi-2 beta antibody tested by immunofluorescence. Top left: HeLa cells stained with Mi...
Western Blotting (WB) image for anti-Chromodomain Helicase DNA Binding Protein 4 (CHD4) (AA 22-155) antibody (ABIN2668534) Mi-2 beta antibody tested by Western blot. Whole-cell extract of mouse splenocytes st...
Produkt verwendet in: Crosswhite, Podsiadlowska, Curtis, Gao, Xia, Srinivasan, Griffin: "CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity." in: The Journal of clinical investigation, Vol. 126, Issue 6, pp. 2254-66, 2016 (PubMed).

Ingram, Curtis, Silasi-Mansat, Lupu, Griffin: "The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis." in: PLoS genetics, Vol. 9, Issue 12, pp. e1004031, 2013 (PubMed).

Curtis, Griffin: "The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling." in: Molecular and cellular biology, Vol. 32, Issue 7, pp. 1312-20, 2012 (PubMed).

McDonel, Demmers, Tan, Watt, Hendrich: "Sin3a is essential for the genome integrity and viability of pluripotent cells." in: Developmental biology, Vol. 363, Issue 1, pp. 62-73, 2012 (PubMed).

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