CEBPA Antikörper

Produktnummer ABIN2664083

Produktdetails anti-CEBPA Antikörper

Target: CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CEBPA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Kreuzreaktivität: Maus

Kreuzreaktivität (Details): weakly cross-reacts with mouse

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: 16C12B70

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CEBPA

Target: CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))

Andere Bezeichnung: C/EBPalpha (CEBPA Produkte)

Synonyme: C/EBP-alpha antikoerper, CEBP antikoerper, C/ebpalpha antikoerper, CBF-A antikoerper, Cebp antikoerper, DBPCEP antikoerper, c/ebpa antikoerper, cb1062 antikoerper, wu:fj20f03 antikoerper, C/EBP antikoerper, C/EBPalpha antikoerper, xC/EBP antikoerper, cC/EBP antikoerper, C/EBP alpha antikoerper, CCAAT/enhancer binding protein alpha antikoerper, CCAAT/enhancer binding protein (C/EBP), alpha antikoerper, CCAAT/enhancer binding protein alpha L homeolog antikoerper, CEBPA antikoerper, Cebpa antikoerper, cebpa antikoerper, cebpa.L antikoerper

Hintergrund: The CCAAT-enhancer binding proteins (C/EBP) are members of the basic region/leucine zipper (bZIP) transcription factors, that bind to the consensus CCAAT sequence in DNA. C/EBPα is expressed in two isoforms: p42 and p30 by ultilizing different translational start codons. The C/EBPα p30 isoform has little to no transactivating activity and acts as an inhibitor. C/EBPα regulates expression of various myeloid-specific genes and is required for myeloid differentiation. C/EBPα has been found to play a key role in adipogenesis, since inhibition of C/EBPα blocks adipocyte differentiation. C/EBPα also regulates cell cycle progression through interactions with cyclin-dependent kinases (CDK) and by inducing the expression of CDK inhibitor p21. Mutations in the C/EBPα gene are associated with the development of acute myeloid leukemia.

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation