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Klra4 Antikörper (PE)

Klra4 Reaktivität: Maus FACS Wirt: Ratte Monoclonal 4E5 PE
Produktnummer ABIN2662800
  • Target Alle Klra4 Produkte
    Klra4 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4))
    Reaktivität
    Maus
    Wirt
    • 3
    Ratte
    Klonalität
    • 3
    Monoklonal
    Konjugat
    • 1
    • 1
    • 1
    Dieser Klra4 Antikörper ist konjugiert mit PE
    Applikation
    • 3
    • 1
    • 1
    Flow Cytometry (FACS)
    Aufreinigung
    The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
    Klon
    4E5
    Isotyp
    IgG2a kappa
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.2 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Protect from prolonged exposure to light. Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    Klra4 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4))
    Andere Bezeichnung
    Ly49D (Klra4 Produkte)
    Synonyme
    Chok antikoerper, Klra32 antikoerper, Ly-49d antikoerper, Ly49d antikoerper, ly49r<129> antikoerper, killer cell lectin-like receptor, subfamily A, member 4 antikoerper, Klra4 antikoerper
    Hintergrund
    Ly49D is a type II transmembrane protein belonging to the Ly49 family of NK-cell receptors in the C-type lectin superfamily. Ly49D is expressed on subsets of natural killer (NK) cells in C57BL/6, C3H/He and SJL mouse strains, but not Balb/c, DBA/2, AKR and CBA/J. The receptors form homodimers that bind to MHC class I alloantigens. Unlike inhibitory Ly49 family members, Ly49D lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) but contains a cytoplasmic immunoreceptor tyrosine-based activation motif. The activating receptor Ly49D delivers stimulatory signals for target cell lysis upon interacting with H2-Dd, Dr and Dsp2, but not with H2b or H2k class I antigens. Cross-linking of Ly49D activates intracellular kinase activity and calcium mobilization in NK cells. In 129/J mice, 4E5 antibody cross-reacts with Ly49O, LY49R and Ly49V.
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