C-Type Lectin Domain Family 1, Member B (CLEC1B) Antikörper (PE)

Produktnummer ABIN2662694

Produktdetails

Target: C-Type Lectin Domain Family 1, Member B (CLEC1B)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: PE

Applikation: Intracellular Flow Cytometry (ICFC)

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Klon: 17D9-CLEC2

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Antigendetails

Target: C-Type Lectin Domain Family 1, Member B (CLEC1B)

Andere Bezeichnung: CLEC2 (CLEC1B Produkte)

Synonyme: 1810061I13Rik antikoerper, CLEC2 antikoerper, CLEC2B antikoerper, PRO1384 antikoerper, QDED721 antikoerper, Clec-2 antikoerper, Clec2 antikoerper, CLEC1B antikoerper, RGD1563517 antikoerper, CLEC9A antikoerper, C-type lectin domain family 1 member B antikoerper, C-type lectin domain family 1, member b antikoerper, C-type lectin domain family 1, member B antikoerper, CLEC1B antikoerper, Clec1b antikoerper

Substanzklasse: Viral Protein

Hintergrund: CLEC-2, also known as CLEC1B and CLEC1B1, is C-type lectin-like receptor with a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). CLEC-2 is highly expressed on resting platelets and megakaryocytes and at a lower levels on several hematopoietic cells including monocytes, macrophages, dendritic cells, and granulocytes. The first ligand that was identified for CLEC-2 was the snake venom toxin rhodocytin, podoplanin has also been identified as an endogenous ligand for CLEC-2. Exposure of platelets to rhodocytin leads tyrosine phosphorylation of the ITAM-like motif and Syk-dependent platelet activation. CLEC-2 also functions as an activation receptor on monoyctes and neutrophils to induce phagocytosis and proinflammatory cytokine production.