BCL2 Antikörper (B-Cell CLL/lymphoma 2) (AA 41-54) (Alexa Fluor 488)

Details for Product anti-BCL2 Antibody No. ABIN2657052, Anbieter: Anmelden zum Anzeigen
Antigen
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • BCL2, apoptosis regulator
  • B cell leukemia/lymphoma 2
  • B-cell CLL/lymphoma 2a
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • bcl2a
  • BCL-2
Epitop
AA 41-54
164
77
66
64
44
31
25
25
24
21
18
15
15
15
13
13
13
11
9
9
7
6
6
5
5
5
5
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
1066
266
220
54
28
22
18
18
5
4
4
3
2
2
2
2
Wirt
Maus
579
553
18
6
2
2
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser BCL2 Antikörper ist konjugiert mit Alexa Fluor 488
53
50
45
41
35
25
23
16
15
15
14
14
14
14
14
14
13
13
7
7
7
6
6
6
6
6
6
6
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
854
398
396
343
338
327
231
196
171
81
42
15
14
13
12
11
9
4
3
2
1
1
1
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen AA 41-54 of human bcl-2 oncoprotein
Klon 100
Isotyp IgG1
Reinigung The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
Andere Bezeichnung Bcl-2 (BCL2 Antibody Abstract)
Hintergrund Bcl-2 is a conserved anti-apoptotic protein that plays important roles in normal immunity. It forms homodimers or heterodimers with other Bcl-2 family members. This protein regulates apoptosis through controlling mitochondrial fusion and fission. Phosphorylation of Bcl-2 has been shown to enhance activity to allow response to extracellular growth-factor-mediated signals. Bcl-2 is also regulated by IRES, miR-15a, miR-16-1 and RNA-BP nucleolin. Chromosome 18q21.3 translocation and overexpression of Bcl-2 is frequently observed in follicular lymphomas and some diffuse large B-cell lymphomas.
Pathways MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagie, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Protect from prolonged exposure to light. Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody (Alexa Fluor 488) (ABIN2657052) anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody (Alexa Fluor 488)
Allgemeine Veröffentlichungen Lin, Medeiros: "The impact of MYC rearrangements and "double hit" abnormalities in diffuse large B-cell lymphoma." in: Current hematologic malignancy reports, Vol. 8, Issue 3, pp. 243-52, 2013 (PubMed).

Kelly, Strasser: "The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy." in: Cell death and differentiation, Vol. 18, Issue 9, pp. 1414-24, 2011 (PubMed).

Tomita: "BCL2 and MYC dual-hit lymphoma/leukemia." in: Journal of clinical and experimental hematopathology : JCEH, Vol. 51, Issue 1, pp. 7-12, 2011 (PubMed).

Rolland, Conradt: "New role of the BCL2 family of proteins in the regulation of mitochondrial dynamics." in: Current opinion in cell biology, Vol. 22, Issue 6, pp. 852-8, 2010 (PubMed).

Willimott, Wagner: "Post-transcriptional and post-translational regulation of Bcl2." in: Biochemical Society transactions, Vol. 38, Issue 6, pp. 1571-5, 2010 (PubMed).

Pezzella, Turley, Kuzu, Tungekar, Dunnill, Pierce, Harris, Gatter, Mason: "bcl-2 protein in non-small-cell lung carcinoma." in: The New England journal of medicine, Vol. 329, Issue 10, pp. 690-4, 1993 (PubMed).

Pezzella, Tse, Cordell, Pulford, Gatter, Mason: "Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation." in: The American journal of pathology, Vol. 137, Issue 2, pp. 225-32, 1990 (PubMed).

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