LASS1 Antikörper

Produktnummer ABIN265220

Der Kaninchen Polyklonal anti-LASS1 Antikörper wird verwendet zum Nachweis von LASS1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für LASS1 Antikörper (ABIN265220)

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LASS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LASS1 Antikörper

Spezifität: This antibody detects Lass1. Detects also GDF1.

Kreuzreaktivität (Details): Cross reacts with GDF1

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide derived from the human Lass1 protein

Anwendungsinformationen

Applikationshinweise: Western blot (1: 400 starting dilution). Positive control: Hypothalamus.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Details zu LASS1

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Andere Bezeichnung: LASS1

Hintergrund: LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may be involved in neurodegenerative diseases and human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane, LAss1 is a multi-pass membrane protein.Synonyms: LAG1, LAG1 longevity assurance homolog 1, LASS1, Longevity assurance gene 1 protein homolog 1, UOG1

Gen-ID: 10715

NCBI Accession: NP_067090

UniProt: P27544