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ATIC Antikörper

ATIC Reaktivität: Human, Maus, Ratte, Drosophila melanogaster, Frosch WB, IHC (fro) Wirt: Maus Monoclonal F38 P7 H9 unconjugated
Produktnummer ABIN264511
  • Target Alle ATIC Antikörper anzeigen
    ATIC (5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC))
    Reaktivität
    • 49
    • 24
    • 20
    • 10
    • 8
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Drosophila melanogaster, Frosch
    Wirt
    • 38
    • 11
    Maus
    Klonalität
    • 39
    • 10
    Monoklonal
    Konjugat
    • 32
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser ATIC Antikörper ist unkonjugiert
    Applikation
    • 30
    • 11
    • 11
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This antibody detects Phosphoribosylaminoimidazolecarboxamide Formyltransferase (ATIC).
    Produktmerkmale
    Synonyms: IMP cyclohydrolase, Inosinicase, IMP synthetase, Bifunctional purine biosynthesis proteinPURH
    Aufreinigung
    Affinity chromatography.
    Immunogen
    Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with asynthetic peptide derived from the human ATIC protein and mouse myeloma Ag8563 cells. Sequence common in Frog, Fruit fly, Rat and Mouse.
    Klon
    F38 P7 H9
    Isotyp
    IgG1
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  • Applikationshinweise
    Western Blot: 1-2 μg/mL. Immunohistochemistry on Paraffin Sections (15 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1 x TBSwithTween (TBST) for 1 min. at room temperature.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Phosphate buffered saline with 0.08 % Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
    Shelf life: one year from despatch.
    Haltbarkeit
    12 months
  • Target
    ATIC (5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC))
    Andere Bezeichnung
    ATIC / PURH (ATIC Produkte)
    Synonyme
    AICAR antikoerper, AICARFT antikoerper, IMPCHASE antikoerper, PURH antikoerper, purH antikoerper, 2610509C24Rik antikoerper, AA536954 antikoerper, AW212393 antikoerper, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase L homeolog antikoerper, bifunctional purine biosynthesis protein PurH antikoerper, bifunctional purine biosynthesis protein purH antikoerper, Bifunctional purine biosynthesis protein purH antikoerper, Bifunctional purine biosynthesis protein PurH antikoerper, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase antikoerper, atic.L antikoerper, purH antikoerper, ATIC antikoerper, Atic antikoerper
    Hintergrund
    The bifunctional purine biosynthesis protein PURH contains phosphoribosylaminoimidazole carboxamide formyltransferase, also designated AICAR transformylase, IMP cyclohydrolase or Inosinicase. AICAR plays an important role in purine biosynthesis, specifically in the production of nucleotides and IMP. Defects in ATIC, the gene encoding for this protein, can cause AICArebosuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-ribotide, also designated ZMP, and its derivatives in erythrocytes and fibroblasts and also excrete very large amounts of AICA-riboside in the urine. Mental retardation, epilepsy, dysmorphic features and congenital blindness are all symptoms of this disease.Synonyms: Bifunctional purine biosynthesis protein PURH, IMP cyclohydrolase, IMP synthetase, Inosinicase
    Gen-ID
    471
    UniProt
    P31939
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