TANK-Binding Kinase 1 (TBK1) Antikörper

Details zu Produkt Nr. ABIN252648, Anbieter: Anmelden zum Anzeigen
Antigen
  • nak
  • t2k
  • TBK1
  • wu:fk70c05
  • zgc:136548
  • NAK
  • T2K
  • 1200008B05Rik
  • AI462036
  • AW048562
  • TANK binding kinase 1 L homeolog
  • TANK binding kinase 1
  • TANK-binding kinase 1
  • tbk1.L
  • TBK1
  • tbk1
  • Tbk1
Reaktivität
Rind (Kuh), Hund, Human, Maus, Ratte (Rattus)
132
84
48
26
25
10
10
9
8
5
5
4
3
2
2
2
2
1
1
Wirt
Maus
105
33
13
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
10
10
9
7
5
5
3
3
1
1
1
1
1
1
1
1
1
Applikation
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Simple Western (SimWes), Western Blotting (WB)
133
70
61
30
23
17
9
6
3
2
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen A synthetic peptide corresponding to amino acids 563-577 (YYQFKKDKAERRLAYC) of human TBK1 was used as immunogen for this antibody (NP_037386).
Klon 108A429
Isotyp IgG1 kappa
Reinigung Protein G purified
Antigen
Andere Bezeichnung TBK1 (TBK1 Antibody Abstract)
Hintergrund Gene Symbol: TBK1
Molekulargewicht Theoretical MW: 84 kDa
Gen-ID 29110
UniProt Q9UHD2
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
Applikations-hinweise Western Blot 1-2 μg/mL, Simple Western 10 μg/mL, Immunohistochemistry 1:20-1:1000, Immunocytochemistry/Immunofluorescence 1:20, Immunohistochemistry-Paraffin 1:20-1:1000In Western Blot this antibody detects a band at 80 kDa. In Simple Western only 10 - 15 μL of the recommended dilution is used per data point. Separated by Size-Wes, Sally Sue/Peggy Sue.
Kommentare

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1.0 mg/mL
Buffer PBS
Buffer contains: 0.05 % Sodium Azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid freeze-thaw cycles
Lagerung 4 °C,-20 °C
Informationen zur Lagerung Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Western blot analysis of TBK1 using ABIN252648 at 2 ug/ml dilution against 10 ug/lane...
Western Blotting (WB) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Western blot analysis of TBK1 in A) human Daudi cell lysate and B) mouse RAW cell lys...
Western Blotting (WB) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Western Blot: TBK1 Antibody (108A429) [ABIN2526485] - Analysis using Azide and BSA Fr...
Western Blotting (WB) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Western Blot: TBK1 Antibody (108A429) [ABIN2526485] - Simple Western lane view shows ...
Western Blotting (WB) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Western Blot: TBK1 Antibody (108A429) [ABIN2526485] - Analysis using Azide and BSA Fr...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Immunohistochemistry-Paraffin: TBK1 Antibody (108A429) [ABIN2526485] - Analysis using...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Immunohistochemistry-Paraffin: TBK1 Antibody (108A429) [ABIN2526485] - Human testis (...
Simple Western (SimWes) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Simple Western: TBK1 Antibody (108A429) [ABIN2526485] - Analysis using Azide and BSA ...
Immunohistochemistry (IHC) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Immunohistochemistry: TBK1 Antibody (108A429) [ABIN2526485] - Antibody was tested in ...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-TANK-Binding Kinase 1 (TBK1) antibody (ABIN252648) Immunocytochemistry/Immunofluorescence: TBK1 Antibody (108A429) - HeLa cells were fi...
Produkt verwendet in: Gulen, Koch, Haag, Schuler, Apetoh, Villunger, Radtke, Ablasser: "Signalling strength determines proapoptotic functions of STING." in: Nature communications, Vol. 8, Issue 1, pp. 427, 2018 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB)

Kwon, Park, Sesaki, Kang: "Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission." in: Biochemical and biophysical research communications, Vol. 493, Issue 1, pp. 737-743, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB)

Slowicka, Vereecke, Mc Guire, Sze, Maelfait, Kolpe, Saelens, Beyaert, van Loo: "Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling." in: European journal of immunology, Vol. 46, Issue 4, pp. 971-80, 2016 (PubMed). (Probematerial (Species): Mouse (Murine)). Weitere Details: Western Blotting

Mukawera, Chartier, Williams, Pagano, Lapointe, Grandvaux: "Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines." in: Redox biology, Vol. 6, pp. 9-18, 2015 (PubMed). (Probematerial (Species): Human). Weitere Details: Western Blotting

Yu, Croxen, Marchiando, Ferreira, Cadwell, Foster, Finlay: "Autophagy facilitates Salmonella replication in HeLa cells." in: mBio, Vol. 5, Issue 2, pp. e00865-14, 2014 (PubMed). (Probematerial (Species): Human). Weitere Details: Western Blotting

Conlon, Burdette, Sharma, Bhat, Thompson, Jiang, Rathinam, Monks, Jin, Xiao, Vogel, Vance, Fitzgerald: "Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5216-25, 2013 (PubMed).

Tamassia, Bazzoni, Le Moigne, Calzetti, Masala, Grisendi, Bussmeyer, Scutera, De Gironcoli, Costantini, Musso, Cassatella: "IFN-β expression is directly activated in human neutrophils transfected with plasmid DNA and is further increased via TLR-4-mediated signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 3, pp. 1500-9, 2012 (PubMed). Weitere Details: Western Blotting

Delhase, Kim, Lee, Naiki-Ito, Chen, Ahn, Murata, Kim, Lautsch, Kobayashi, Shirai, Karin, Nakanishi: "TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 4, pp. E177-86, 2012 (PubMed).

Ogasawara, Sasaki, Itoh, Tokudome, Kondo, Ito, Tanida, Kamiya, Kataoka, Joh, Kasugai: "Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction." in: Journal of clinical biochemistry and nutrition, Vol. 48, Issue 2, pp. 154-60, 2011 (PubMed). (Probematerial (Species): Human). Weitere Details: Western Blotting

Berthet, Damien, Hamzeh-Cognasse, Pozzetto, Garraud, Cognasse: "Toll-like receptor 4 signal transduction in platelets: novel pathways." in: British journal of haematology, Vol. 151, Issue 1, pp. 89-92, 2010 (PubMed). (Probematerial (Species): Human). Weitere Details: Western Blotting

Marchlik, Thakker, Carlson, Jiang, Ryan, Marusic, Goutagny, Kuang, Askew, Roberts, Benoit, Zhou, Ling, Pfeifer, Stedman, Fitzgerald, Lin, Hall: "Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality." in: Journal of leukocyte biology, Vol. 88, Issue 6, pp. 1171-80, 2010 (PubMed). (Probematerial (Species): Mouse (Murine)). Weitere Details: Western Blotting

Joung, Park, Rani, Takeuchi, Akira, Lee: "Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 1, pp. 499-507, 2010 (PubMed). Weitere Details: Western Blotting

Radtke, ORiordan: "Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1." in: Cellular microbiology, Vol. 10, Issue 11, pp. 2197-207, 2008 (PubMed).

McCoy, Carpenter, Pålsson-McDermott, Gearing, ONeill: "Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation." in: The Journal of biological chemistry, Vol. 283, Issue 21, pp. 14277-85, 2008 (PubMed). (Probematerial (Species): Human). Weitere Details: Western Blotting

Tamassia, Le Moigne, Rossato, Donini, McCartney, Calzetti, Colonna, Bazzoni, Cassatella: "Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 6563-73, 2008 (PubMed). (Probematerial (Species): Human). Weitere Details: Western Blotting

Merimi, Klener, Szynal, Cleuter, Kerkhofs, Burny, Martiat, Van den Broeke: "Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code." in: Journal of virology, Vol. 81, Issue 11, pp. 5929-39, 2007 (PubMed).

Aksoy, Albarani, Nguyen, Laes, Ruelle, De Wit, Willems, Goldman, Goriely: "Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells." in: Blood, Vol. 109, Issue 7, pp. 2887-93, 2007 (PubMed). (Probematerial (Species): Human). Weitere Details: Western Blotting

Péant, Diallo, Lessard, Delvoye, Le Page, Saad, Mes-Masson: "Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer." in: Molecular cancer research : MCR, Vol. 5, Issue 1, pp. 87-94, 2007 (PubMed). (Probematerial (Species): Human). Weitere Details: Western Blotting

Tamassia, Le Moigne, Calzetti, Donini, Gasperini, Ear, Cloutier, Martinez, Fabbri, Locati, Mantovani, McDonald, Cassatella: "The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 11, pp. 7344-56, 2007 (PubMed). (Probematerial (Species): Human).

Sankar, Chan, Romanow, Li, Bates: "IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines." in: Cellular signalling, Vol. 18, Issue 7, pp. 982-93, 2006 (PubMed). (Probematerial (Species): Human).

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