CDK5R1 Antikörper (FITC)
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- Target Alle CDK5R1 Antikörper anzeigen
- CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CDK5R1 Antikörper ist konjugiert mit FITC
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Antibody Array (AA)
- Spezifität
- Detects ~23 kDa.
- Kreuzreaktivität
- Huhn, Meerschweinchen, Human, Maus, Kaninchen, Saccharomyces cerevisiae
- Aufreinigung
- Protein G Purified
- Immunogen
- Recombinant human full length p23 protein
- Klon
- JJ6
- Isotyp
- IgG1
- Top Product
- Discover our top product CDK5R1 Primärantikörper
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- Applikationshinweise
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- WB (1:2000) IHC (1:100)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
- Kommentare
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0.5 μg/ml of ABIN2486462 was sufficient for detection of p23 in 20 μg of heat shocked cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Conjugated antibodies should be stored at 4°C
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- Target
- CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
- Andere Bezeichnung
- p23 (CDK5R1 Produkte)
- Synonyme
- CDK5P35 antikoerper, CDK5R antikoerper, NCK5A antikoerper, p23 antikoerper, p25 antikoerper, p35 antikoerper, p35nck5a antikoerper, cdk5r1 antikoerper, zgc:92814 antikoerper, CDK5R1 antikoerper, Cdk5r antikoerper, P25/P35 antikoerper, D11Bwg0379e antikoerper, Xp35.1 antikoerper, cyclin dependent kinase 5 regulatory subunit 1 antikoerper, cyclin-dependent kinase 5, regulatory subunit 1b (p35) antikoerper, cyclin-dependent kinase 5 regulatory subunit 1 antikoerper, S100 calcium binding protein A9 antikoerper, cyclin-dependent kinase 5, regulatory subunit 1 (p35) antikoerper, cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog antikoerper, CDK5R1 antikoerper, cdk5r1b antikoerper, Cdk5r1 antikoerper, S100A9 antikoerper, cdk5r1.L antikoerper
- Hintergrund
- P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the HSP90-progesterone receptor complex along with HSP70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
- Gen-ID
- 10728
- NCBI Accession
- NP_006592
- UniProt
- Q15185
- Pathways
- Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
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