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SLC12A3 Antikörper (AA 74-95) (Atto 390)

SLC12A3 Reaktivität: Ratte WB, IHC, ICC, IF, IEM Wirt: Kaninchen Polyclonal Atto 390
Produktnummer ABIN2486282
  • Target Alle SLC12A3 Antikörper anzeigen
    SLC12A3 (Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3))
    Bindungsspezifität
    • 16
    • 10
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 74-95
    Reaktivität
    • 34
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 42
    • 4
    Kaninchen
    Klonalität
    • 42
    • 4
    Polyklonal
    Konjugat
    • 12
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SLC12A3 Antikörper ist konjugiert mit Atto 390
    Applikation
    • 25
    • 16
    • 14
    • 14
    • 13
    • 13
    • 12
    • 10
    • 9
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoelectron Microscopy (IEM)
    Spezifität
    Detects ~160 kDa.
    Kreuzreaktivität
    Hund, Human, Maus, Ratte
    Aufreinigung
    Affinity Purified
    Immunogen
    Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal
    Top Product
    Discover our top product SLC12A3 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:200)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2486282 was sufficient for detection of NCC3 in 10 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    SLC12A3 (Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3))
    Andere Bezeichnung
    NCC (SLC12A3 Produkte)
    Synonyme
    SLC12A3 antikoerper, slc12a3 antikoerper, DKFZp469N2315 antikoerper, NCC antikoerper, NCCT antikoerper, TSC antikoerper, AI035291 antikoerper, solute carrier family 12 member 3 antikoerper, solute carrier family 12 (sodium/chloride transporter), member 3 antikoerper, solute carrier family 12, member 3 antikoerper, SLC12A3 antikoerper, slc12a3.2 antikoerper, Slc12a3 antikoerper
    Hintergrund
    NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis (1). Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC (2). Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension (1). Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat (3).
    Gen-ID
    54300, 6559
    NCBI Accession
    NP_062218, NP_000330
    UniProt
    P55018, P55017
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