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SCN3B Antikörper (AA 1-215) (HRP)

SCN3B Reaktivität: Ratte WB, ICC, IF Wirt: Maus Monoclonal S396-29 HRP
Produktnummer ABIN2485588
  • Target Alle SCN3B Antikörper anzeigen
    SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))
    Bindungsspezifität
    • 15
    • 11
    • 1
    • 1
    • 1
    • 1
    AA 1-215
    Reaktivität
    • 33
    • 13
    • 9
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    Ratte
    Wirt
    • 27
    • 11
    Maus
    Klonalität
    • 28
    • 10
    Monoklonal
    Konjugat
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SCN3B Antikörper ist konjugiert mit HRP
    Applikation
    • 36
    • 13
    • 13
    • 10
    • 10
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    Detects ~40 kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1-215 (full-length) of rat NavBeta3
    Klon
    S396-29
    Isotyp
    IgG2b
    Top Product
    Discover our top product SCN3B Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    A 1:100 dilution of ABIN2485588 was sufficient for detection of NavBeta3 in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))
    Andere Bezeichnung
    NaVbeta3 (SCN3B Produkte)
    Synonyme
    1110001K16Rik antikoerper, 4833414B02Rik antikoerper, Scnb3 antikoerper, HSA243396 antikoerper, SCNB3 antikoerper, sodium voltage-gated channel beta subunit 3 antikoerper, sodium channel, voltage-gated, type III, beta antikoerper, SCN3B antikoerper, Scn3b antikoerper
    Hintergrund
    Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).
    Gen-ID
    245956
    NCBI Accession
    NP_620797
    UniProt
    Q9JK00
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