ATP7B Antikörper (AA 3-21) (APC)

Produktnummer ABIN2485173

Produktdetails anti-ATP7B Antikörper (APC)

Target: ATP7B (ATPase, Cu++ Transporting, beta Polypeptide (ATP7B))

Bindungsspezifität: AA 3-21

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATP7B Antikörper ist konjugiert mit APC

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Spezifität: Detects ~160 kDa in rat brain membrane preparations.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein G Purified

Immunogen: Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2

Klon: S62-29

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN2485173 was sufficient for detection of Copper-transporting ATPase2 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu ATP7B

Target: ATP7B (ATPase, Cu++ Transporting, beta Polypeptide (ATP7B))

Andere Bezeichnung: ATP7B (ATP7B Produkte)

Synonyme: PWD antikoerper, WC1 antikoerper, WD antikoerper, WND antikoerper, Atp7a antikoerper, tx antikoerper, Hts antikoerper, PINA antikoerper, Wd antikoerper, ATP7B antikoerper, ATPase copper transporting beta antikoerper, ATPase, Cu++ transporting, beta polypeptide antikoerper, ATPase, Cu++ transporting, beta polypeptide (Wilson disease) antikoerper, copper-transporting ATPase 2 antikoerper, ATP7B antikoerper, Atp7b antikoerper, atp7b antikoerper, LOC592143 antikoerper

Hintergrund: The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene, A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver, characterized by neurological symptoms and hepatic damage.

Gen-ID: 540

NCBI Accession: NP_000044

UniProt: B7ZLR4

Pathways: Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process