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NALCN Antikörper (AA 1659-1738) (Alkaline Phosphatase (AP))

NALCN Reaktivität: Ratte WB, ICC, IF Wirt: Maus Monoclonal S187-7 Alkaline Phosphatase (AP)
Produktnummer ABIN2483027
  • Target Alle NALCN Antikörper anzeigen
    NALCN (Sodium Leak Channel, Non-Selective (NALCN))
    Bindungsspezifität
    • 12
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 1659-1738
    Reaktivität
    • 15
    • 7
    • 3
    • 1
    Ratte
    Wirt
    • 15
    • 7
    Maus
    Klonalität
    • 15
    • 7
    Monoklonal
    Konjugat
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NALCN Antikörper ist konjugiert mit Alkaline Phosphatase (AP)
    Applikation
    • 16
    • 12
    • 12
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    Detects ~200 kDa.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
    Klon
    S187-7
    Isotyp
    IgG1
    Top Product
    Discover our top product NALCN Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2483027 was sufficient for detection of NALCN in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    NALCN (Sodium Leak Channel, Non-Selective (NALCN))
    Andere Bezeichnung
    NALCN (NALCN Produkte)
    Synonyme
    VGCNL1 antikoerper, zgc:113349 antikoerper, CanIon antikoerper, bA430M15.1 antikoerper, A530023G15Rik antikoerper, AI849508 antikoerper, Vgcnl1 antikoerper, sodium leak channel, non-selective antikoerper, NALCN antikoerper, nalcn antikoerper, Nalcn antikoerper
    Hintergrund
    NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.
    Gen-ID
    266760
    NCBI Accession
    NP_705894
    UniProt
    Q6Q760
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