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HMOX2 Antikörper (FITC)

HMOX2 Reaktivität: Ratte WB, IHC, IP Wirt: Kaninchen Polyclonal FITC
Produktnummer ABIN2482163
  • Target Alle HMOX2 Antikörper anzeigen
    HMOX2 (Heme Oxygenase (Decycling) 2 (HMOX2))
    Reaktivität
    • 74
    • 45
    • 35
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Ratte
    Wirt
    • 81
    • 4
    • 1
    • 1
    Kaninchen
    Klonalität
    • 84
    • 3
    Polyklonal
    Konjugat
    • 34
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HMOX2 Antikörper ist konjugiert mit FITC
    Applikation
    • 75
    • 38
    • 30
    • 19
    • 18
    • 13
    • 13
    • 10
    • 9
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Spezifität
    Detects ~36 kDa.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein A Purified
    Immunogen
    Rat native full-length HO-2 purified from testes
    Top Product
    Discover our top product HMOX2 Primärantikörper
  • Applikationshinweise
    • WB (1:500)
    • IHC (1:1000)
    • IP (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    2 μg/ml of ABIN2482163 was sufficient for detection of HO-2 in 20 μg of Rat brain lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    HMOX2 (Heme Oxygenase (Decycling) 2 (HMOX2))
    Andere Bezeichnung
    HO-2 (HMOX2 Produkte)
    Synonyme
    HO-2 antikoerper, HO2 antikoerper, HMOX2 antikoerper, Ho-2 antikoerper, im:6909100 antikoerper, si:dkey-44g23.7 antikoerper, AtHO2 antikoerper, T9J22.22 antikoerper, T9J22_22 antikoerper, heme oxygenase 2 antikoerper, hmox2 antikoerper, ho-2 antikoerper, heme oxygenase 2 antikoerper, Heme oxygenase 2 antikoerper, heme oxygenase 2, putative antikoerper, heme oxygenase 2a antikoerper, heme oxygenase 2 L homeolog antikoerper, HMOX2 antikoerper, Hmox2 antikoerper, HO2 antikoerper, ho2 antikoerper, CNF01200 antikoerper, CPR_0203 antikoerper, CGB_F5120W antikoerper, hmox2a antikoerper, hmox2.L antikoerper
    Hintergrund
    Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is sequestered to ferritin (1). These products have important physiological effects as carbon monoxide is a potent vasodilator, biliverdin and bilirubin are potent antioxidants, and the free iron increases oxidative stress and regulates the expression of many mRNAs (2). There are three isoforms of heme-oxygenase, HO-1, HO-2 and HO-3, however HO-1 and HO-2 are the major isoforms as they both have been identified in mammals (3). HO-1, also known as heat shock protein 32, is an inducible isoform activated by most oxidative stress inducers, cytokines, inflammatory agents and heat shock. HO-2 is a constitutive isoform which is expressed under homeostatic conditions. HO-1 is also considered to be a cytoprotective factor in that free heme is highly reactive and cytotoxic, and secondly, carbon monoxide is a mediator inhibiting the inflammatory process and bilirubin is a scavenger for reactive oxygen, both of which are the end products of heme catalyzation (4). It has also been shown that HO-1 deficiency may cause reduced stress defense, a pro-inflammatory tendency (5), susceptibility to atherosclerotic lesion formation (6), endothelial cell injury, and growth retardation (7). Up-regulation of HO-1 is therefore said to be one of the major defense mechanisms of oxidative stress (4).
    Gen-ID
    79239
    NCBI Accession
    NP_077363
    UniProt
    P23711
    Pathways
    Transition Metal Ion Homeostasis
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