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ADRA2B Antikörper (AA 200-299)

ADRA2B Reaktivität: Human WB Wirt: Huhn Polyclonal unconjugated
Produktnummer ABIN2467937
  • Target Alle ADRA2B Antikörper anzeigen
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Bindungsspezifität
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 200-299
    Reaktivität
    • 22
    • 6
    • 4
    Human
    Wirt
    • 23
    • 3
    Huhn
    Klonalität
    • 23
    • 3
    Polyklonal
    Konjugat
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ADRA2B Antikörper ist unkonjugiert
    Applikation
    • 17
    • 9
    • 6
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    Immunoaffinity Purified
    Top Product
    Discover our top product ADRA2B Primärantikörper
  • Applikationshinweise
    alpha-2B adrenergic receptor antibody can be used for the detection of alpha-2B adrenergic receptor by Western Blot.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Phosphate-Buffered Saline. No preservatives added.
    Konservierungsmittel
    Without preservative
    Handhabung
    As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    ADRA2B antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.
  • Target
    ADRA2B (Adrenergic, alpha-2B-, Receptor (ADRA2B))
    Andere Bezeichnung
    ADRA2B (ADRA2B Produkte)
    Synonyme
    ADRA2L1 antikoerper, ADRA2RL1 antikoerper, ADRARL1 antikoerper, ALPHA2BAR antikoerper, alpha-2BAR antikoerper, Adra-2b antikoerper, [a]2B antikoerper, alpha2-C2 antikoerper, alpha2B antikoerper, ADRA2B antikoerper, zgc:194747 antikoerper, Adra2b antikoerper, adrenoceptor alpha 2B antikoerper, adrenergic receptor, alpha 2b antikoerper, adrenergic, alpha-2B-, receptor antikoerper, adrenoceptor alpha 2C antikoerper, ADRA2B antikoerper, Adra2b antikoerper, ADRA2C antikoerper, adra2b antikoerper
    Hintergrund
    FUNCTION: alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

    SUMMARY: alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This protein is the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization, this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This protein contains no introns in either its coding or untranslated sequences.
    Molekulargewicht
    50 kDa (calculated)
    Gen-ID
    151
    NCBI Accession
    NP_000673
    UniProt
    P18089
    Pathways
    EGFR Signaling Pathway, cAMP Metabolic Process
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