MXI1 Antikörper

Produktnummer ABIN2463882

Produktdetails anti-MXI1 Antikörper

Target: MXI1 (MAX Interactor 1 (MXI1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MXI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MXI1.

Anwendungsinformationen

Applikationshinweise: MXI1 antibody can be used for detection of MXI1 by ELISA at 1:62500. MXI1 antibody can be used for detection of MXI1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store MXI1 antibody at -20 °C.

Details zu MXI1

Target: MXI1 (MAX Interactor 1 (MXI1))

Andere Bezeichnung: MXI1 (MXI1 Produkte)

Synonyme: mxi antikoerper, mad2 antikoerper, mxd2 antikoerper, xmxi1 antikoerper, MGC89544 antikoerper, MXI1 antikoerper, etID309773.22 antikoerper, fb16b12 antikoerper, fb55f03 antikoerper, wu:fb16b12 antikoerper, wu:fb55f03 antikoerper, wu:fd06a08 antikoerper, wu:fz74f10 antikoerper, ENSMUSG00000067085 antikoerper, Gm10197 antikoerper, Mad2 antikoerper, bHLHc11 antikoerper, MXI-WR antikoerper, MAD2 antikoerper, MXD2 antikoerper, MXI antikoerper, MAX interactor 1, dimerization protein antikoerper, max interactor 1, dimerization protein antikoerper, MAX interactor 1, dimerization protein L homeolog antikoerper, mxi1 antikoerper, MXI1 antikoerper, Mxi1 antikoerper, mxi1.L antikoerper

Hintergrund: Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The MXI1 gene encodes a transcriptional repressor protein thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in MXI1 are frequently found in patients with prostate tumors. Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.

Molekulargewicht: 33 kDa

Gen-ID: 4601

NCBI Accession: NP_569157

Pathways: Maintenance of Protein Location