Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

SIGLEC12 Antikörper

SIGLEC12 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2463321
  • Target Alle SIGLEC12 Antikörper anzeigen
    SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
    Reaktivität
    • 28
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 29
    • 3
    • 1
    Kaninchen
    Klonalität
    • 31
    • 2
    Polyklonal
    Konjugat
    • 21
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SIGLEC12 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 11
    • 8
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    Antibody is purified by peptide affinity chromatography method.
    Immunogen
    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SIGLEC12.
    Top Product
    Discover our top product SIGLEC12 Primärantikörper
  • Applikationshinweise
    SIGLEC12 antibody can be used for detection of SIGLEC12 by ELISA at 1:1562500. SIGLEC12 antibody can be used for detection of SIGLEC12 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
    Konzentration
    1 mg/mL
    Buffer
    Antibody is lyophilized in PBS buffer with 2 % sucrose.
    Handhabung
    As with any antibody avoid repeat freeze-thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    For short periods of storage (days) store at 4 °C. For longer periods of storage, store SIGLEC12 antibody at -20 °C.
  • Target
    SIGLEC12 (Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
    Andere Bezeichnung
    SIGLEC12 (SIGLEC12 Produkte)
    Synonyme
    S2V antikoerper, SIGLECL1 antikoerper, SLG antikoerper, Siglec-XII antikoerper, sialic acid binding Ig like lectin 12 (gene/pseudogene) antikoerper, sialic acid binding Ig like lectin 12 antikoerper, sialic acid binding Ig-like lectin 12 antikoerper, SIGLEC12 antikoerper
    Hintergrund
    Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. SIGLEC12 is a member of the SIGLEC3-like subfamily of SIGLECs. SIGLEC12, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor.Western blots using four different antibodies against four unique regions of this protein target confirm the same apparent molecular weight in our tests.Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
    Molekulargewicht
    63 kDa
    Gen-ID
    89858
    NCBI Accession
    NP_443729
    UniProt
    Q96PQ1
Sie sind hier:
Kundenservice