NR4A2 Antikörper

Produktnummer ABIN2460549

Produktdetails anti-NR4A2 Antikörper

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Reaktivität: Human, Maus, Ratte, Hund, Zebrafisch (Danio rerio), Drosophila melanogaster

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR4A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR4A2.

Anwendungsinformationen

Applikationshinweise: NR4A2 antibody can be used for detection of NR4A2 by ELISA at 1:62500. NR4A2 antibody can be used for detection of NR4A2 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store NR4A2 antibody at -20 °C.

Details zu NR4A2

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Andere Bezeichnung: NR4A2 (NR4A2 Produkte)

Hintergrund: NR4A2 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. The protein may act as a transcription factor. Mutations in NR4A2 gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of NR4A2 gene may be associated with rheumatoid arthritis.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.

Molekulargewicht: 66 kDa, 64 kDa, 68 kDa, 64 kDa, 65 kDa, 60 kDa, 68 kDa, 70 kDa

Gen-ID: 4929

NCBI Accession: NP_006177

UniProt: P43354

Pathways: Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway