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CHFR Antikörper

CHFR Reaktivität: Human, Maus, Ratte ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2458725
  • Target Alle CHFR Antikörper anzeigen
    CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
    Reaktivität
    • 45
    • 13
    • 12
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 41
    • 3
    • 1
    Kaninchen
    Klonalität
    • 42
    • 3
    Polyklonal
    Konjugat
    • 18
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser CHFR Antikörper ist unkonjugiert
    Applikation
    • 26
    • 24
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Aufreinigung
    Antibody is purified by peptide affinity chromatography method.
    Immunogen
    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHFR.
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    Discover our top product CHFR Primärantikörper
  • Applikationshinweise
    CHFR antibody can be used for detection of CHFR by ELISA at 1:312500. CHFR antibody can be used for detection of CHFR by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
    Konzentration
    1 mg/mL
    Buffer
    Antibody is lyophilized in PBS buffer with 2 % sucrose.
    Handhabung
    As with any antibody avoid repeat freeze-thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    For short periods of storage (days) store at 4 °C. For longer periods of storage, store CHFR antibody at -20 °C.
  • Target
    CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
    Andere Bezeichnung
    CHFR (CHFR Produkte)
    Synonyme
    RNF116 antikoerper, RNF196 antikoerper, CHFR antikoerper, fc43f10 antikoerper, si:dkey-69h6.7 antikoerper, wu:fc43f10 antikoerper, rnf116 antikoerper, rnf196 antikoerper, 5730484M20Rik antikoerper, C230082M18 antikoerper, checkpoint with forkhead and ring finger domains antikoerper, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase antikoerper, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog antikoerper, CHFR antikoerper, chfr antikoerper, Chfr antikoerper, chfr.L antikoerper
    Hintergrund
    CHFR is an E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when they are exposed to microtubule poisons. It acts in early prophase before chromosome condensation, when the centrosome moves apart from each other along the periphery of the nucleus. CHFR probably promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress caused by microtubule poisons.
    Molekulargewicht
    69 kDa
    Gen-ID
    55743
    NCBI Accession
    NP_060693
    UniProt
    Q96EP1
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