NFX1 Antikörper

Produktnummer ABIN2458113

Produktdetails anti-NFX1 Antikörper

Target: NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NFX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NFX1.

Anwendungsinformationen

Applikationshinweise: NFX1 antibody can be used for detection of NFX1 by ELISA at 1:62500. NFX1 antibody can be used for detection of NFX1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Konzentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handhabung: As with any antibody avoid repeat freeze-thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: For short periods of storage (days) store at 4 °C. For longer periods of storage, store NFX1 antibody at -20 °C.

Details zu NFX1

Target: NFX1 (Nuclear Transcription Factor, X-Box Binding 1 (NFX1))

Andere Bezeichnung: NFX1 (NFX1 Produkte)

Synonyme: NFX1 antikoerper, NFX2 antikoerper, 1300017N15Rik antikoerper, 3000003M19Rik antikoerper, NFX.1 antikoerper, TEG-42 antikoerper, Tex42 antikoerper, nuclear transcription factor, X-box binding 1 antikoerper, nuclear transcription factor, x-box binding 1 antikoerper, NFX1 antikoerper, CpipJ_CPIJ011986 antikoerper, nfx1 antikoerper, Nfx1 antikoerper

Hintergrund: NFX1 binds to the X-box motif of MHC class II genes and represses their expression. NFX1 may play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. NFX1 mediates E2-dependent ubiquitination.MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.

Molekulargewicht: 113 kDa

Gen-ID: 4799

NCBI Accession: NP_667344