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HCV Core Protein Antikörper (AA 13-124, AA 369-704) (FITC)

HCV C Reaktivität: Hepatitis C Virus (HCV) IF, IHC Wirt: Maus Monoclonal H6-29 FITC
Produktnummer ABIN2451998
  • Target Alle HCV Core Protein (HCV C) Antikörper anzeigen
    HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
    Bindungsspezifität
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 13-124, AA 369-704
    Reaktivität
    • 60
    • 5
    • 3
    • 1
    Hepatitis C Virus (HCV)
    Wirt
    • 45
    • 18
    • 4
    Maus
    Klonalität
    • 45
    • 22
    Monoklonal
    Konjugat
    • 39
    • 10
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HCV Core Protein Antikörper ist konjugiert mit FITC
    Applikation
    • 45
    • 35
    • 16
    • 13
    • 12
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC)
    Spezifität
    Specific to human HCV core antigen of genotype 1b.
    Kreuzreaktivität (Details)
    Not tested in other genotypes.
    Sterilität
    Sterile filtered
    Immunogen
    A part of the core region (nucleotides 369-704, aa 13-124) of HCV genotype 1b expressed in E. coli
    Klon
    H6-29
    Isotyp
    IgG2a kappa
  • Applikationshinweise
    1. Immunofluorescence staining
    2. Immunohistochemistry
    Kommentare

    Conjugate: FITC conjugated, [FITC] / [IgG] = 6.7

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.6 mg/mL
    Buffer
    PBS with 50 % Glycerol
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C
  • Brass, Moradpour, Blum: "Molecular virology of hepatitis C virus (HCV): 2006 update." in: International journal of medical sciences, Vol. 3, Issue 2, pp. 29-34, (2006) (PubMed).

    Manabe, Fuke, Tanishita, Kaji, Gomi, Yoshida, Mori, Takamizawa, Yosida, Okayama: "Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3." in: Virology, Vol. 198, Issue 2, pp. 636-44, (1994) (PubMed).

    Hiramatsu, Hayashi, Haruna, Kasahara, Fusamoto, Mori, Fuke, Okayama, Kamada: "Immunohistochemical detection of hepatitis C virus-infected hepatocytes in chronic liver disease with monoclonal antibodies to core, envelope and NS3 regions of the hepatitis C virus genome." in: Hepatology (Baltimore, Md.), Vol. 16, Issue 2, pp. 306-11, (1992) (PubMed).

    Takamizawa, Mori, Fuke, Manabe, Murakami, Fujita, Onishi, Andoh, Yoshida, Okayama: "Structure and organization of the hepatitis C virus genome isolated from human carriers." in: Journal of virology, Vol. 65, Issue 3, pp. 1105-13, (1991) (PubMed).

    Kato, Hijikata, Ootsuyama, Nakagawa, Ohkoshi, Sugimura, Shimotohno: "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 24, pp. 9524-8, (1991) (PubMed).

  • Target
    HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
    Andere Bezeichnung
    HCV Core Protein (HCV C Produkte)
    Substanzklasse
    Viral Protein
    Hintergrund
    Hepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive sense single-stranded RNA virus in the family Flaviviridae and the principal cause of parenteral non-A, non-B hepatitis. The virus genome consists of a single open reading frame of approximately 9.4 kb which encodes a single polyprotein of about 3,010 amino acids. The polyprotein is processed by host cell and viral proteases into four structural proteins (core, envelope1 and 2, and p7) and six non-structural proteins (NS2, 3, 4a, 4b, 5a, and 5b) necessary for viral replication. HCV core protein (191 aa) is not only a component of nucleocapsid but also has multiple functions and is thought to be a pathogenic factor for hepatitis. It also participates in some cellular processes, including transcriptional regulation and cellular transduction. HCV core antigen is used as diagnostic marker for HCV infection.
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