5DII antikoerper, D2 antikoerper, DIOII antikoerper, SelY antikoerper, TXDI2 antikoerper, AI324267 antikoerper, Deio2 antikoerper, cb684 antikoerper, DIO2 antikoerper, dio2-A antikoerper, 5dii antikoerper, sely antikoerper, txdi2 antikoerper, iodothyronine deiodinase 2 antikoerper, deiodinase, iodothyronine, type II antikoerper, deiodinase, iodothyronine, type 2 L homeolog antikoerper, deiodinase, iodothyronine, type 2 antikoerper, type II iodothyronine deiodinase antikoerper, DIO2 antikoerper, Dio2 antikoerper, dio2 antikoerper, dio2.L antikoerper, LOC100861220 antikoerper
Hintergrund
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.