TAB1 Antikörper

Produktnummer ABIN2430413

Produktdetails anti-TAB1 Antikörper

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAB1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human TAB1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TAB1

Target: TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))

Andere Bezeichnung: TAB1 (TAB1 Produkte)

Synonyme: 3'-Tab1 antikoerper, MAP3K7IP1 antikoerper, 2310012M03Rik antikoerper, Map3k7ip1 antikoerper, b2b449Clo antikoerper, TGF-beta activated kinase 1 (MAP3K7) binding protein 1 antikoerper, TGF-beta activated kinase 1/MAP3K7 binding protein 1 antikoerper, TAB1 antikoerper, Tab1 antikoerper

Hintergrund: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.

Pathways: TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades