JMJD2D Antikörper

Produktnummer ABIN2430337

Produktdetails anti-JMJD2D Antikörper

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JMJD2D Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human KDM4D

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu JMJD2D

Target: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Andere Bezeichnung: KDM4D (KDM4D Produkte)

Synonyme: JMJD2D antikoerper, 4932416A15 antikoerper, Jmjd2d antikoerper, KDM4D antikoerper, lysine demethylase 4D antikoerper, lysine-specific demethylase 4D antikoerper, lysine (K)-specific demethylase 4D antikoerper, KDM4D antikoerper, LOC524768 antikoerper, Kdm4d antikoerper, LOC617971 antikoerper, LOC100067461 antikoerper, LOC698455 antikoerper, LOC100514356 antikoerper

Hintergrund: JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.

Molekulargewicht: Calculated MW: 59 kDa

Pathways: Warburg Effekt