IRAK1BP1 Antikörper

Produktnummer ABIN2421755

Produktdetails anti-IRAK1BP1 Antikörper

Target: IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRAK1BP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human IRAK1BP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Handhabung: Avoid freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu IRAK1BP1

Target: IRAK1BP1 (Interleukin-1 Receptor-Associated Kinase 1 Binding Protein 1 (IRAK1BP1))

Andere Bezeichnung: IRAK1BP1 (IRAK1BP1 Produkte)

Synonyme: AIP70 antikoerper, SIMPL antikoerper, 4921528N06Rik antikoerper, AI851240 antikoerper, Aabp3 antikoerper, Aip70 antikoerper, Simpl antikoerper, zgc:112481 antikoerper, interleukin 1 receptor associated kinase 1 binding protein 1 antikoerper, interleukin-1 receptor-associated kinase 1 binding protein 1 antikoerper, IRAK1BP1 antikoerper, Irak1bp1 antikoerper, irak1bp1 antikoerper

Hintergrund: SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.

Molekulargewicht: Calculated MW: 29 kDa