VDAC1 Antikörper (Voltage-Dependent Anion Channel 1)

Details for Product anti-VDAC1 Antibody No. ABIN223288
Antigen
  • vdac1
  • VDAC1
  • 5076
  • ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1
  • ATVDAC1
  • T22N4.9
  • T22N4_9
  • voltage dependent anion channel 1
  • PORIN
  • VDAC-1
  • AL033343
  • Vdac5
  • fa13f11
  • wu:fa13f11
  • zgc:85830
  • voltage-dependent anion channel 1 S homeolog
  • voltage-dependent anion channel 1
  • voltage dependent anion channel 1
  • vdac1.S
  • vdac1
  • VDAC1
  • Vdac1
Reaktivität
Rind (Kuh), Human, Maus, Kaninchen, Ratte (Rattus)
187
105
96
7
7
5
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
Wirt
Kaninchen
141
51
Klonalität
Polyklonal
Konjugat
Dieser VDAC1 Antikörper ist unkonjugiert
7
5
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
168
113
61
52
47
24
10
10
3
2
2
2
1
1
1
1
1
Optionen
Immunogen Synthetic peptide surrounding amino acid 189 of human VDAC
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN412963.
Isotyp IgG
Spezifität The antibody recognizes ~31 kDa VDAC/Porin from samples of human, mouse, rat, bovine, pig, and rabbit origins.
Reinigung Affinity purified
Plasmids, Primers & others Plasmide, Primers & weitere VDAC1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung VDAC/Porin (VDAC1 Antibody Abstract)
Hintergrund The Voltage-Dependent Anion Channel (VDAC or mitochondrial Porin)I is an outer membrane mitochondrial protein. The VDAC protein is thoμght to form the major pores throμgh which adenine nucleotides are transferred throμgh the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, ANT, and CypD is thoμght to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis.
Synonyms: VDAC1, VDAC-1 , MGC111064 , hVDAC1, Porin
Gen-ID 7416
UniProt P21796
Applikations-hinweise Western blotting (0.5-4 μg/mL) and Immunohistochemistry (2.5 μg/mL). However, the optimal concentrations should be determined individually. The antibody recognizes ~31 kDa VDAC/Porin from samples of human, mouse, rat, bovine, pig, and rabbit origins.
Kommentare

Suggested positive control:
Western Blot: 3T3 cell lysate. IHC: Liver tissue

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer 100 μg (0.5 mg/mL) affinity purified rabbit anti-VDAC/Porin polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.
Konservierungs-mittel Thimerosal (Merthiolate)
Vorsichtsmaßnahmen This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung The antibody solution should be gently mixed before use.
Lagerung -20 °C
Informationen zur Lagerung For long-term storage, aliquot and freeze at -70 °C.
Haltbarkeit 12 months
Bilder des Herstellers
Image no. 1 for anti-Voltage-Dependent Anion Channel 1 (VDAC1) antibody (ABIN223288) Western blot analysis of VDAC/Porinwith 3T3 cell lysate.
Produkt verwendet in: Ghelli, Tropeano, Calvaruso, Marchesini, Iommarini, Porcelli, Zanna, De Nardo, Martinuzzi, Wibrand, Vissing, Kurelac, Gasparre, Selamoglu, Daldal, Rugolo: "The cytochrome b p.278Y>C mutation causative of a multisystem disorder enhances superoxide production and alters supramolecular interactions of respiratory chain complexes." in: Human molecular genetics, Vol. 22, Issue 11, pp. 2141-51, 2013 (PubMed).

Bortner, Scoltock, Sifre, Cidlowski: "Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes." in: The Journal of biological chemistry, Vol. 287, Issue 9, pp. 6284-95, 2012 (PubMed).

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