Caspase 6 Antikörper (Caspase 6, Apoptosis-Related Cysteine Peptidase) (C-Term)

Details for Product anti-CASP6 Antibody No. ABIN222958
Antigen
Epitop
C-Term, Large Subunit, active
50
45
27
15
15
13
11
10
10
7
6
5
5
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
285
123
118
16
4
4
3
3
2
Wirt
Kaninchen
293
14
8
Klonalität
Polyklonal
Biologische Aktivität
Active
Konjugat
Dieser Caspase 6 Antikörper ist unkonjugiert
22
16
12
8
8
8
6
6
6
6
6
6
3
3
3
3
3
Applikation
Western Blotting (WB)
259
130
129
62
40
31
21
10
10
8
7
5
3
1
1
Optionen
Immunogen Synthetic peptide surrounding AA mapping to the C-terminus of the large fragment of human caspase-6
Isotyp IgG
Spezifität The antibody detects the large subunit (18 kDa) of the active caspase-6.
The antibody does not recognize other caspases.
Reinigung Affinity purified
Antigen
Andere Bezeichnung Caspase-6 (CASP6 Antibody Abstract)
Hintergrund Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase-3, caspase-6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase-6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
Synonyms: CASP6, CASP-6 , MCH2
Gen-ID 839
Pathways Apoptose, Caspase Kaskade in der Apoptose
Applikations-hinweise Western blotting (0.5-4 μg/mL) and immunofluorescence. However, the optimal conditions should be determined individually. The antibody detects the large subunit (18 kDa) of the active caspase-6. The antibody does not recognize other caspases.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer 100 μg (0.5 mg/mL) affinity purified rabbit anti-active caspase-6 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.
Konservierungs-mittel Thimerosal (Merthiolate)
Vorsichtsmaßnahmen This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung The antibody solution should be gently mixed before use.
Lagerung -20 °C
Informationen zur Lagerung For long-term storage, aliquot and freeze at -70 °C.
Haltbarkeit 12 months
Produkt verwendet in: Vohra, Sasaki, Miller, Chang, DiAntonio, Milbrandt: "Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 41, pp. 13729-38, 2010 (PubMed).