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JAML Antikörper (FITC)

AMICA1 Reaktivität: Human FACS, IF, IP, WB Wirt: Maus Monoclonal BV16 FITC
Pubmed (4 Referenzen)
Produktnummer ABIN2192221
$885.41
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle JAML (AMICA1) Antikörper anzeigen
    JAML (AMICA1)
    Reaktivität
    • 31
    • 2
    • 1
    Human
    Wirt
    • 21
    • 7
    • 3
    • 2
    Maus
    Klonalität
    • 25
    • 7
    Monoklonal
    Konjugat
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Dieser JAML Antikörper ist konjugiert mit FITC
    Applikation
    • 30
    • 24
    • 8
    • 3
    • 3
    • 2
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    BV16
  • Applikationshinweise
    It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 1 % bovine serum
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Vetrano, Rescigno, Cera, Correale, Rumio, Doni, Fantini, Sturm, Borroni, Repici, Locati, Malesci, Dejana, Danese: "Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease." in: Gastroenterology, Vol. 135, Issue 1, pp. 173-84, (2008) (PubMed).

    Luo, Zhuo, Fukuhara, Rizzolo: "Effects of culture conditions on heterogeneity and the apical junctional complex of the ARPE-19 cell line." in: Investigative ophthalmology & visual science, Vol. 47, Issue 8, pp. 3644-55, (2006) (PubMed).

    Faure, Cerini, Paul, Berland, Dignat-George, Brunet: "The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro." in: International immunology, Vol. 18, Issue 10, pp. 1453-9, (2006) (PubMed).

    Bazzoni, Martinez-Estrada, Orsenigo, Cordenonsi, Citi, Dejana: "Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20520-6, (2000) (PubMed).

  • Target
    JAML (AMICA1)
    Andere Bezeichnung
    Junctional Adhesion Molecule (AMICA1 Produkte)
    Synonyme
    RGD1562572, AMICA, CREA7-1, CREA7-4, Gm638, JAML, Crea7, junction adhesion molecule like, Jaml, JAML
    Hintergrund
    The FITC conjugated monoclonal antibody BV16 recognizes the human junction adhesion molecule (JAM)-A. Together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3), JAM-A belongs to a family of adhesion proteins with a V-C2 immunoglobulin domain organization and their molecular weight is about 30-40 kDa. JAMs are important for a variety of cellular processes, including tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. JAM-A is expressed by endothelial and epithelial cells, platelets, neutrophils, monocytes, lymphocytes and erythrocytes. Like all other JAMs, JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-A also plays an important role in leukocyte transmigration. Leukocyte transmigration can be blocked by antibodies and by soluble JAM-A/Fc fusion proteins. Homophilic JAM-A interactions between leukocytes and the endothelium but also heterophilic interactions of JAM-A with the beta 2-integrin leukocyte function-associated antigen-1 (LFA-1) are considered to actively guide leukocytes during transmigration. Several studies imply a role for JAM-A in the initiation of atherosclerosis, since JAM-A is upregulated on early atherosclerotic endothelium. Adhesion of the activated platelets on activated endothelium is mediated by homophilic interactions of JAM-A. PAM-1, JAM-1, JAMA, CD321, platelet F11 receptor Aliases Fusion protein consisting of the extracellular domain of human JAM and the Fc portion of human IgGs Immunogen Mouse IgG1
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