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Endostatin (ES) Antikörper Primary Antibody

ES Reaktivität: Human IA, IHC (fro), FACS, IHC (p), WB Wirt: Maus Monoclonal 1837-46 unconjugated
Pubmed (2 Referenzen)
Produktnummer ABIN2192047
$659.59
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle Endostatin (ES) Antikörper anzeigen
    Endostatin (ES)
    Reaktivität
    • 50
    • 29
    • 6
    • 1
    Human
    Wirt
    • 52
    • 7
    • 2
    Maus
    Klonalität
    • 52
    • 9
    Monoklonal
    Konjugat
    • 32
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Unkonjugiert
    Applikation
    • 49
    • 38
    • 27
    • 12
    • 7
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    1837-46
  • Applikationshinweise
    For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For staining of paraffin sections antigen retrieval (microwave irradiation (2x7 minutes) in citrate buffer) is advised.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Deininger, Fimmen, Kremsner, Meyermann, Schluesener: "Accumulation of endostatin/collagenXVIII in brains of patients who died with cerebral malaria." in: Journal of neuroimmunology, Vol. 131, Issue 1-2, pp. 216-21, (2002) (PubMed).

    Deininger, Fimmen, Thal, Schluesener, Meyermann: "Aberrant neuronal and paracellular deposition of endostatin in brains of patients with Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 24, pp. 10621-6, (2002) (PubMed).

  • Target
    Endostatin (ES)
    Andere Bezeichnung
    Endostatin (ES Produkte)
    Synonyme
    KNO, KNO1, KS, collagen type XVIII alpha 1 chain, collagen, type XVIII, alpha 1, COL18A1, Col18a1
    Substanzklasse
    Chemical
    Hintergrund
    Monoclonal antibody 1837-46 reacts with endostatin, a 20 kDa C-terminal fragment of collagen XVIII. Endostatin is able to evoke non-uniform response for proliferation, cell mount and migration of entothelial cells, with different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type. Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality. Tumor cell migration and invasion was greatly reduced in the endostatin treated animals. Endostatin is non-toxic and does not induce acquired drug resistance and has therefore become a potent new therapy strategy in solid neoplasias. This therapy appear to have high potential not only for the treatment of gliomas, the most common brain tumours, but also of other tumours. The ability of endostatin 2+ to inhibit neoangiogenesis is mediated, at least in part, by Zn binding and elastase processing. Widespread endostatin expression was found in elastic fibers in vessel walls and in some other basement membrane zones. Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.
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