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S100A8 Antikörper (S100 Calcium Binding Protein A8) Primary Antibody

S100A8 Reaktivität: Human IA, FACS, WB Wirt: Maus Monoclonal 7C12-4 unconjugated
Pubmed (1 reference)
Produktnummer ABIN2192036
$605.98
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle S100A8 Antikörper anzeigen
    S100A8
    Reaktivität
    • 95
    • 55
    • 35
    • 14
    • 11
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    Human
    Wirt
    • 82
    • 41
    • 10
    • 4
    • 1
    Maus
    Klonalität
    • 94
    • 44
    Monoklonal
    Konjugat
    • 70
    • 22
    • 17
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser S100A8 Antikörper ist unkonjugiert
    Applikation
    • 86
    • 53
    • 49
    • 33
    • 19
    • 16
    • 15
    • 14
    • 13
    • 12
    • 10
    • 7
    • 7
    • 6
    • 3
    • 3
    • 1
    Immunoassay (IA), Flow Cytometry (FACS), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    7C12-4
  • Applikationshinweise
    For flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Robinson, Tessier, Poulsom, Hogg: "The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3658-65, (2002) (PubMed).

  • Target
    S100A8
    Andere Bezeichnung
    s100a8 (S100A8 Produkte)
    Synonyme
    60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, Mrp8, S100A8, 60B8Ag, AI323541, B8Ag, CFAg, Caga, p8, MRP-8, S100 calcium binding protein A8, S100 calcium binding protein A8 (calgranulin A), S100A8, S100a8
    Hintergrund
    The monoclonal antibody 7C12/4 recognizes an epitope on the S100A8 (MRP-8) protein. The calcium- binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60 % of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti- S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils.
    Pathways
    Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteine
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