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COL2 Antikörper (CII-J1 epitope)

COL2 Reaktivität: Maus IHC (p), IHC (fro), Func, D, IA Wirt: Maus Monoclonal M2139 unconjugated
Produktnummer ABIN2191818
  • Target Alle COL2 Antikörper anzeigen
    COL2 (Collagen, Type II (COL2))
    Bindungsspezifität
    • 16
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    CII-J1 epitope
    Reaktivität
    • 45
    • 32
    • 29
    • 23
    • 18
    • 13
    • 11
    • 4
    • 1
    Maus
    Wirt
    • 42
    • 12
    • 10
    • 4
    Maus
    Klonalität
    • 56
    • 12
    Monoklonal
    Konjugat
    • 34
    • 12
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser COL2 Antikörper ist unkonjugiert
    Applikation
    • 51
    • 38
    • 22
    • 20
    • 15
    • 14
    • 13
    • 13
    • 9
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Detection (D), Immunoassay (IA)
    Sterilität
    0.2 μm filtered
    Klon
    M2139
    Top Product
    Discover our top product COL2 Primärantikörper
  • Applikationshinweise
    For immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS and 0.1 % bovine serum albumin
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Target
    COL2 (Collagen, Type II (COL2))
    Andere Bezeichnung
    Collagen Type II (COL2 Produkte)
    Synonyme
    PT antikoerper, RPRGL2 antikoerper, THPH1 antikoerper, Cf-2 antikoerper, Cf2 antikoerper, FII antikoerper, thrombin antikoerper, prothrombin antikoerper, CAP18 antikoerper, Cnlp antikoerper, Cramp antikoerper, FALL39 antikoerper, MCLP antikoerper, coagulation factor II, thrombin antikoerper, coagulation factor II antikoerper, cathelicidin antimicrobial peptide antikoerper, Cuticle collagen 2 antikoerper, collagen type II alpha 1 chain antikoerper, F2 antikoerper, Camp antikoerper, col-2 antikoerper, COL2A1 antikoerper
    Hintergrund
    The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA). The monocolonal antibody M2139 has been shown to induce CAIA in naive mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody CIIC1, binding to the C1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. The monoclonal antibody M2139 is cross reactive with rat, bovine, chicken and human CII.
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