JAM3 Antikörper

Produktnummer ABIN2191807

Produktdetails anti-JAM3 Antikörper

Target: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser JAM3 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA), Detection (D), Inhibition Assay (InhA)

Sterilität: 0.2 μm filtered

Klon: CRAM-18 F26

Anwendungsinformationen

Applikationshinweise: For immunohistology and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For inhibition of biological activity, dilutions have to be made according to the amounts of JAM-C to be inhibited.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-JAM3 Antikörper (ABIN2191807)

Johnson-Léger, Aurrand-Lions, Beltraminelli, Fasel, Imhof: "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration." in: Blood, Vol. 100, Issue 7, pp. 2479-86, (2002) (PubMed).

Details zu JAM3

Target: JAM3 (Junctional Adhesion Molecule 3 (JAM3))

Andere Bezeichnung: Junctional Adhesion Molecule-C (JAM3 Produkte)

Hintergrund: The monoclonal antibody CRAM-18 F26 recognizes junctional adhesion molecule-C (JAM-C) also known as JAM-2, a 45 kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. Monoclonal antibody CRAM-18 F26 also reacts with human JAM-C. In humans, JAM-C expression is not restricted to endothelial cells, but is also expressed on human lymphocytes.