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CCL2 Antikörper (Chemokine (C-C Motif) Ligand 2) (Biotin) Primary Antibody

CCL2 Reaktivität: Maus FACS, IHC (p), WB Wirt: Ratte Monoclonal ECE-2 Biotin
Pubmed (3 Referenzen)
Produktnummer ABIN2191759
$412.65
Zzgl. Versandkosten $45.00
50 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle CCL2 Antikörper anzeigen
    CCL2
    Reaktivität
    • 118
    • 63
    • 55
    • 17
    • 9
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 132
    • 65
    • 7
    • 7
    • 5
    • 3
    • 3
    Ratte
    Klonalität
    • 149
    • 73
    Monoklonal
    Konjugat
    • 125
    • 37
    • 16
    • 10
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CCL2 Antikörper ist konjugiert mit Biotin
    Applikation
    • 155
    • 89
    • 75
    • 28
    • 27
    • 26
    • 18
    • 18
    • 16
    • 15
    • 15
    • 14
    • 13
    • 13
    • 11
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Kreuzreaktivität (Details)
    Cross reactivity: Human : No
    Sterilität
    0.2 μm filtered
    Klon
    ECE-2
    Isotyp
    IgG1
  • Applikationshinweise
    For immunohistochemistry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Tieu, Lee, Sun, Lejeune, Recinos, Ju, Spratt, Guo, Milewicz, Tilton, Brasier: "An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice." in: The Journal of clinical investigation, Vol. 119, Issue 12, pp. 3637-51, (2009) (PubMed).

    Kimura, Sumiyoshi, Samukawa, Satake, Sakanaka: "Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism." in: European journal of pharmacology, Vol. 584, Issue 2-3, pp. 415-23, (2008) (PubMed).

    Zoja, Liu, Donadelli, Abbate, Testa, Corna, Taraboletti, Vecchi, Dong, Rollins, Bertani, Remuzzi: "Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice." in: Journal of the American Society of Nephrology : JASN, Vol. 8, Issue 5, pp. 720-9, (1997) (PubMed).

  • Target
    CCL2
    Andere Bezeichnung
    Monocyte Chemoattractant Protein 1 (CCL2 Produkte)
    Synonyme
    GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, AI323594, JE, Scya2, Sigje, MCP-1A, MCP1A, C-C motif chemokine ligand 2, chemokine (C-C motif) ligand 2, C-C motif chemokine 2, CCL2, Ccl2, LOC101120093
    Hintergrund
    The monoclonal antibody ECE.2 recognizes mouse monocyte chemoattractant protein 1 (MCP-1). The murine JE gene encodes the monocyte-specific cytokine monocyte chemotactic protein 1 (MCP- 1). MCP-1 is a CC chemokine of 76 amino acids (~11 kDa) and is chemotactic for monocytes and basophils but not neutrophils and eosinophils. MCP-1 is expressed by smooth muscle cells (SMC), macrophages, endothelial cells, keratinocytes and fibroblasts in response to inflammatory stimuli such as interleukin 1β and tumor necrosis factor α. MCP-1 has been implicated in a variety of inflammatory processes, including inflammatory bowel disease, rheumatoid arthritis, asthma, nephritis, and parasitic and viral infections. MCP-1 antigen is not detected in the endothelium or SMC of normal arteries. MCP-1 has also been shown to exhibit biological activities other than chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK (CC-Chemokine-activated killer) MCP-1 signals via the CCR2 receptor, and is critical for aneurysm formation because of its
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylierungen bei SARS-CoV-2 Infektion
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