SULT1B1 Antikörper (Sulfotransferase Family 1B Member 1) (AA 2-296)

Details for Product anti-SULT1B1 Antibody No. ABIN1998891, Anbieter: Anmelden zum Anzeigen
Antigen
  • ST1B1
  • ST1B2
  • SULT1B2
  • St2b2
  • SULT1B
  • cSULT1B1
  • MGC80677
  • SULT1B1
  • sulfotransferase family 1B member 1
  • sulfotransferase family 1B, member 1
  • sulfotransferase family cytosolic 1B member 1
  • sulfotransferase family 1B member 1 S homeolog
  • sulfotransferase family, cytosolic, 1B, member 1
  • SULT1B1
  • Sult1b1
  • sult1b1.S
  • sult1b1
  • LOC100624541
Epitop
AA 2-296
11
10
8
5
5
4
3
3
1
1
1
1
Reaktivität
Human
55
4
3
3
2
2
1
1
Wirt
Kaninchen
48
5
2
Klonalität
Polyklonal
Konjugat
Dieser SULT1B1 Antikörper ist unkonjugiert
3
3
3
2
2
2
Applikation
ELISA
51
32
6
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Recombinant Human SULT1B1 protein (ABIN2004404)
Isotyp IgG
Spezifität Human SULT1B1
Produktmerkmale Produced in rabbits immunized with purified, recombinant Human SULT1B1 (rh SULT1B1, ABIN2004404 NP_055280.2, Leu 2-Ile 296,. Total IgG was purified by Protein A affinity chromatography.
Reinigung purified by Protein A affinity chromatography
Sterilität 0.2 μm filtered
Plasmids, Primers & others Plasmide, Primers & weitere SULT1B1 products on genomics-online (e.g. as negative or positive controls)
Antigen Sulfotransferase Family 1B Member 1 (SULT1B1)
Andere Bezeichnung SULT1B1 (SULT1B1 Antibody Abstract)
Hintergrund Sulfotransferase family cytosolic 1B member 1, also known as Sulfotransferase 1B1, Sulfotransferase 1B2, Thyroid hormone sulfotransferase, SULT1B1 and ST1B2, is a cytoplasm protein which belongs to the,sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1B1 is highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression of SULT1B1 was observed in the lung, placenta and thymus. SULT1B1 catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. SULT1B1 sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.
NCBI Accession NP_055280.2
Applikations-hinweise ELISA: 0.5-1.0 μg/mL
This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human SULT1B1. The detection limit for Human SULT1B1 is approximately 0.00245 ng/well.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Konservierungs-mittel Without preservative
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung 4 °C,-20 °C,-80 °C
Informationen zur Lagerung This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Haltbarkeit 12 months
Allgemeine Veröffentlichungen Dombrovski, Dong, Bochkarev, Plotnikov: "Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP)." in: Proteins, Vol. 64, Issue 4, pp. 1091-4, 2006 (PubMed).

Kester, Kaptein, Roest, van Dijk, Tibboel, Meinl, Glatt, Coughtrie, Visser: "Characterization of rat iodothyronine sulfotransferases." in: American journal of physiology. Endocrinology and metabolism, Vol. 285, Issue 3, pp. E592-8, 2003 (PubMed).

Fujita, Nagata, Ozawa, Sasano, Yamazoe: "Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases." in: Journal of biochemistry, Vol. 122, Issue 5, pp. 1052-61, 1998 (PubMed).

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