ABCG1 Antikörper (ATP-Binding Cassette, Sub-Family G (WHITE), Member 1) (AA 359-387)

Details for Product anti-ABCG1 Antibody No. ABIN1981354, Anbieter: Anmelden zum Anzeigen
Antigen
  • ABCG1
  • zgc:162197
  • ABC8
  • WHITE1
  • AW413978
  • Abc8
  • White
  • ATP binding cassette subfamily G member 1
  • ATP-binding cassette, sub-family G (WHITE), member 1
  • ABCG1
  • abcg1
  • Abcg1
Epitop
AA 359-387, Center
22
16
9
7
7
6
5
4
4
3
2
2
1
1
1
1
Reaktivität
Human
96
63
45
13
13
12
12
1
1
1
1
1
1
Wirt
Kaninchen
93
5
Klonalität
Polyklonal
Konjugat
Dieser ABCG1 Antikörper ist unkonjugiert
6
5
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
72
45
25
23
19
14
13
11
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Verwendungszweck Polyclonal Antibody to detect ABCG1 in human samples
Immunogen This ABCG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-387 AA from the central region of human ABCG1.
Isotyp IgG
Spezifität Polyclonal Antibody detects ABCG1 in human samples
Produktmerkmale Polyclonal Antibody to detect ABCG1 in human samples
Reinigung This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Andere Bezeichnung ABCG1 (ABCG1 Antibody Abstract)
Hintergrund ABCG1 (ATP-binding cassette sub-family G member 1), a transporter protein primarily involved in macrophage lipid homeostasis, localizes to intracellular compartments associated with ER /Golgi membranes, and its expression is highest in macrophage-rich tissue such as spleen, lung, and thymus as well as in brain. ABCG1 form heterodimers with heterologous ABCG partners and functional heterodimerization with ABCG4 has been of great interest because brain cells, mainly neurons and astrocytes, depict high expression of both transporters. ABCG1 is involved in the export of a variety of lipids (in conjunction with ABCA1) including cholesterol and phospholipids from macrophages to HDL. Macrophage lipid export is the first step in the reverse cholesterol transport pathway that exports cholesterol from peripheral cells to circulating lipoproteins for eventual excretion via liver. Cholesterol export to lipoprotein acceptors is compromised in macrophage foam cells, one of the early hallmarks of atherosclerosis. Moreover, ABCG1 plays role in T cells/inflammation, brain lipid homeostasis and its expression increases in macrophages of Tangier disease patients.
Synonyms: ABCG1, ABC8, WHT1, ATP-binding cassette sub-family G member 1, ATP-binding cassette transporter 8, White protein homolog
UniProt P45844
Forschungsgebiet Cancer, Atherosclerosis, Metabolism, Glia marker
Applikationshinweise Western blot: ~1:1000, FACS: ~1:10-1:50, IHC: ~1:50-1:100.
Kommentare

Suggested positive control:
Western blot: 293 cell lysate, IHC: human hepatocarcinoma, FACS: HepG2 cells

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer 100 μL of antibody in PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung The antibody solution should be gently mixed before use.
Lagerung -20 °C
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 (ABCG1) (AA 359-387), (Center) antibody (ABIN1981354) anti-ATP-Binding Cassette, Sub-Family G (WHITE), Member 1 (ABCG1) (AA 359-387), (Center) antibody
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