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NPAS3 Antikörper (Center)

NPAS3 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1887738
  • Target Alle NPAS3 Antikörper anzeigen
    NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))
    Bindungsspezifität
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 7
    Kaninchen
    Klonalität
    • 7
    Polyklonal
    Konjugat
    • 7
    Dieser NPAS3 Antikörper ist unkonjugiert
    Applikation
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    28 amino acid peptide from near the center of human NPAS3.
    Top Product
    Discover our top product NPAS3 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Handhabung
    Avoid freezing and thawing repeatly.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 4 °C for short term use.Store at -20 °C for long term preservation.
  • Target
    NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))
    Andere Bezeichnung
    NPAS3 (NPAS3 Produkte)
    Synonyme
    trh antikoerper, mop6 antikoerper, pasd6 antikoerper, MGC145768 antikoerper, MOP6 antikoerper, PASD6 antikoerper, bHLHe12 antikoerper, 4930423H22Rik antikoerper, neuronal PAS domain protein 3 antikoerper, npas3 antikoerper, NPAS3 antikoerper, Npas3 antikoerper
    Hintergrund
    Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia.It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region.NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities.Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin.These results demonstrate the essential role played by NPAS3 during structural and functional brain development.At least three isoforms of NPAS3 are known to exist.
    Synonyms: Neuronal PAS domain-containing protein 3, member of Pas protein 6, MOP6
    UniProt
    Q8IXF0
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